SAT0639 ACTIVE JAK/STAT SIGNALING IN CIRCULATING LEUCOCYTES DEFINES DISTINCT IMMUNOLOGIC ENDOTYPES OF RHEUMATOID ARTHRITIS

Background:

In rheumatoid arthritis (RA) stratification is considered an important step towards the development of patient-tailored therapeutic concepts. The fact that less than 50% of RA patients experience a substantial improvement in response to any single biologic therapy has brought up the idea that yet unidentified subtypes of RA (endotypes) might exist. This concept is in line with distinct microscopic patterns of synovitis found...