Original paper
Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation
Abstract
Cysteine acts both as a building unit for protein translation and as the limiting substrate for glutathione synthesis to support the cellular antioxidant system. In addition to transporter-mediated uptake, cellular cysteine can also be synthesized from methionine through the transsulfuration pathway. Here, we investigate the regulation of transsulfuration and its role in sustaining cell proliferation upon extracellular cysteine limitation, a...
Paper Details
Title
Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation
Published Date
Nov 1, 2019
Journal
Volume
30
Issue
5
Pages
865 - 876.e5
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Notes
History