Liraglutide Treatment Ameliorates Neurotoxicity Induced by Stable Silencing of Pin1
Volume: 20, Issue: 20, Pages: 5064 - 5064
Published: Oct 12, 2019
Abstract
Post-translational modulation of peptidylprolyl isomerase Pin1 might link impaired glucose metabolism and neurodegeneration, being Pin1 effectors target for the glucagon-Like-Peptide1 analog liraglutide. We tested the hypotheses in Pin1 silenced cells (SH-SY5Y) treated with 2-deoxy-d-glucose (2DG) and methylglyoxal (MG), stressors causing altered glucose trafficking, glucotoxicity and protein glycation. Rescue by liraglutide was investigated....
Paper Details
Title
Liraglutide Treatment Ameliorates Neurotoxicity Induced by Stable Silencing of Pin1
Published Date
Oct 12, 2019
Volume
20
Issue
20
Pages
5064 - 5064
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