Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas

•RASA5 is normally widely expressed but epigenetically silenced in multiple cancers•Epigenetic disruption of RASA5 is associated with tumor progression in patients•RASA5 suppresses RAS signaling, depending on its RasGAP catalytic activity•RASA5 functions as a tumor suppressor through inhibiting EMT and metastasis Aberrant RAS signaling activation is common in cancers with even few Ras mutations, indicating alternative dysregulation other than...