Heterogeneous alpha-cell population modeling of glucose-induced inhibition of electrical activity

Glucagon release from the pancreatic alpha-cells is regulated by glucose, but the underlying mechanisms are far from understood. It is known that the alpha-cell population is very heterogeneous, but – compared to the insulin-secreting beta-cells – the consequences of this cell-to-cell variation are much less studied. Since the alpha-cells are not electrically coupled, large differences in the single cell responses are to be expected, and this...