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Journal of Theoretical Biology
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#1Julien FlaigH-Index: 2
#2Nicolas Houy (University of Lyon)H-Index: 7
Last.Philippe Michel (ECL: École centrale de Lyon)H-Index: 39
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Abstract In a vaccination game, individuals respond to an epidemic by engaging in preventive behaviors that, in turn, influence the course of the epidemic. Such feedback loops need to be considered in the cost effectiveness evaluations of public health policies. We elaborate on the example of mandatory measles vaccination and the role of its anticipation. Our framework is a SIR compartmental model with fully rational forward looking agents who can therefore anticipate on the effects of the manda...
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#1Fan Xia (Xi'an Jiaotong University)
#2Feng Deng (CDC: Centers for Disease Control and Prevention)
Last.Xiaodan Sun (Xi'an Jiaotong University)H-Index: 4
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Abstract Repeated outbreaks of Hand, foot and mouth disease (HFMD) infections have been observed in recent decades and dominated by various enteroviral serotypes. In particular, enterovirus 71 (EV-A71), coxsackievirus A16 (CV-A16) and coxsackievirus A6 (CV-A6) dominated the prevalence of HFMD infections alternatively in recent years with various outbreak sizes in Baoji, a city of Shaanxi Province in Northwest China. Estimating the reproduction number for various enteroviruses serotypes in northw...
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#1Mark Broom (City University London)H-Index: 24
#2Igor V. Erovenko (UNCG: University of North Carolina at Greensboro)H-Index: 2
Last.Jan Rychtář (VCU: Virginia Commonwealth University)
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Abstract The dispersal of individuals within an animal population will depend upon local properties intrinsic to the environment that differentiate superior from inferior regions as well as properties of the population. Competing concerns can either draw conspecifics together in aggregation, such as collective defence against predators, or promote dispersal that minimizes local densities, for instance to reduce competition for food. In this paper we consider a range of models of non-independent ...
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#1Lianhui Shi (China University of Geosciences)
#2Jianing Wu (THU: Tsinghua University)H-Index: 11
Last.Shaoze Yan (THU: Tsinghua University)H-Index: 17
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Abstract Bees (Apidae) are flower-visiting insects that possess highly efficient mouthparts for the ingestion of nectar and other sucrose fluids. Their mouthparts are composed of mandibles and a tube-like proboscis. The proboscis forms a food canal, which encompasses a protrusible and hairy tongue to load and imbibe nectar, representing a fluid-feeding technique with a low Reynolds number. The western honey bee, Apis mellifera ligustica, can rhythmically erect the tongue microtrichia to regulate...
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#1N. TsurH-Index: 1
#2Yuri KoganH-Index: 12
Last.Zvia AgurH-Index: 20
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Abstract Immune checkpoint inhibitors (ICI) are becoming widely used in the treatment of metastatic melanoma. However, the ability to predict the patient's benefit from these therapeutics remains an unmet clinical need. Mathematical models that predict melanoma patients’ response to ICI can contribute to better informed clinical decisions. Here, we developed a simple mathematical population model for pembrolizumab-treated advanced melanoma patients, and analyzed the local and global dynamics of ...
1 CitationsSource
#1Andrew Glover (Heriot-Watt University)
#2Andrew White (Heriot-Watt University)H-Index: 30
Abstract Superinfection exclusion is a phenomenon whereby the co-infection of a host with a secondary pathogen is prevented due to a current infection by another closely-related pathogenic strain. We construct a novel vector-host mathematical model for two pathogens that exhibit superinfection exclusion and simultaneously account for vaccination strategies against them. We then derive the conditions under which an endemic disease will prevent the establishment of another through the action of su...
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#1Francesco Montefusco (UNIPD: University of Padua)H-Index: 6
#2Giuliana Cortese (UNIPD: University of Padua)H-Index: 12
Last.Morten Gram Pedersen (UNIPD: University of Padua)H-Index: 18
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Abstract Glucagon release from the pancreatic alpha-cells is regulated by glucose, but the underlying mechanisms are far from understood. It is known that the alpha-cell population is very heterogeneous, but – compared to the insulin-secreting beta-cells – the consequences of this cell-to-cell variation are much less studied. Since the alpha-cells are not electrically coupled, large differences in the single cell responses are to be expected, and this variation may contribute to the confusion re...
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#1Yovani Marrero-Ponce (University of Valencia)H-Index: 26
#2Julio E. Terán (USFQ: Universidad San Francisco de Quito)H-Index: 1
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Abstract Novel 3D protein descriptors based on bilinear, quadratic and linear algebraic maps in R n are proposed. The latter employs the kth 2-tuple (dis) similarity matrix to codify information related to covalent and non-covalent interactions in these biopolymers. The calculation of the inter-amino acid distances is generalized by using several dis-similarity coefficients, where normalization procedures based on the simple stochastic and mutual probability schemes are applied. A new local-frag...
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#1Sofia Almeida (French Institute of Health and Medical Research)
#2Madalena Chaves (IRIA: French Institute for Research in Computer Science and Automation)H-Index: 17
Last.Franck Delaunay (French Institute of Health and Medical Research)H-Index: 22
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Abstract The molecular oscillator of the mammalian circadian clock consists in a dynamical network of genes and proteins whose main regulatory mechanisms occur at the transcriptional level. From a dynamical point of view, the mechanisms leading to an oscillatory solution with an orderly protein peak expression and a clear day/night phase distinction remain unclear. Our goal is to identify the essential interactions needed to generate phase opposition between the activating CLOCK:BMAL1 and the re...
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#1Tapiwa Ganyani (University of Hasselt)H-Index: 2
#2Christel Faes (University of Hasselt)H-Index: 23
Last.Niel Hens (University of Antwerp)H-Index: 34
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Abstract Recently, the generalized-growth model was introduced as a flexible approach to characterize growth dynamics of disease outbreaks during the early ascending phase. In this work, by using classical maximum likelihood estimation to obtain parameter estimates, we evaluate the impact of varying levels of overdispersion on the inference of the growth scaling parameter through comparing Poisson and Negative binomial models. In particular, under exponential and sub-exponential growth scenarios...
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