Original paper
De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens
Abstract
High-throughput CRISPR-Cas9 knockout screens using a tiling-sgRNA design permit in situ evaluation of protein domain function. Here, to facilitate de novo identification of essential protein domains from such screens, we propose ProTiler, a computational method for the robust mapping of CRISPR knockout hyper-sensitive (CKHS) regions, which refer to the protein regions associated with a strong sgRNA dropout effect in the screens. Applied to a...
Paper Details
Title
De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens
Published Date
Oct 4, 2019
Journal
Volume
10
Issue
1
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Notes
History