Original paper

The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2

Volume: 9, Issue: 1
Published: Oct 1, 2019
Abstract
Transient receptor potential melastatin channel subfamily member 2 (TRPM2) has an essential role in protecting cell viability through modulation of oxidative stress. TRPM2 is highly expressed in cancer. When TRPM2 is inhibited, mitochondria are dysfunctional, ROS levels are increased, and cell viability is reduced. Here, the importance of NF-E2-related factor (Nrf2) in TRPM2-mediated suppression of oxidant stress was explored. In TRPM2 depleted...
Paper Details
Title
The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2
Published Date
Oct 1, 2019
Volume
9
Issue
1
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