Influence of mouth rinse use on the enterosalivary pathway and blood pressure regulation: A systematic review

The enterosalivary nitrate-nitrite-nitric oxide (NO) pathway results in systemic generation of NO from dietary inorganic nitrate to promote vasodilation and blood pressure regulation. Commensal bacteria in the oral cavity with nitrate-reducing properties underpin the efficiency of this pathway, as they facilitate the reduction of nitrate to nitrite—a critical activation step preceding NO formation. However, common antibacterial mouth rinses rid...