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The Usefulness of Definitive Screening Design for a Quality by Design Approach as Demonstrated by a Pharmaceutical Study of Orally Disintegrating Tablet

Published on Oct 1, 2019in Chemical & Pharmaceutical Bulletin1.405
· DOI :10.1248/cpb.c19-00553
Keisuke Takagaki2
Estimated H-index: 2
(Hoshi University),
Terushi Ito (University of Toyama)+ 3 AuthorsYoshinori Onuki15
Estimated H-index: 15
(University of Toyama)
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Abstract In the pharmaceutical industry, the systematic optimization of formulation using Quality by Design (QbD) approach is economic, highly precise and ensures product quality. The current endeavor was aimed to prepare escitalopram ultra-fast melting tablets (UFMTs) based on QbD approach using suspension spray-coating technique. The (32) full factorial design was applied to obtain the optimal formulation in terms of; mannitol level (X1) and partially pre-gelatinized starch level (PPGS; X2) as...
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