Original paper
Individualized treatment with denosumab in children with osteogenesis imperfecta – follow up of a trial cohort
Abstract
Osteogenesis imperfecta (OI) is a rare disease leading to hereditary bone fragility. Nearly 90% of cases are caused by mutations in the collagen genes COL1A1/A2 (classical OI) leading to multiple fractures, scoliosis, short stature and nonskeletal findings as blue sclera, hypermobility of joints, bone pain and delayed motor function development. Bisphosphonates are used in most moderate and severely affected patients assuming that an increase of...
Paper Details
Title
Individualized treatment with denosumab in children with osteogenesis imperfecta – follow up of a trial cohort
Published Date
Sep 18, 2019
Volume
14
Issue
1
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History