Original paper

Genetic determinants of cellular addiction to DNA polymerase theta

Volume: 10, Issue: 1
Published: Sep 19, 2019
Abstract
Polymerase theta (Pol θ, gene name Polq) is a widely conserved DNA polymerase that mediates a microhomology-mediated, error-prone, double strand break (DSB) repair pathway, referred to as Theta Mediated End Joining (TMEJ). Cells with homologous recombination deficiency are reliant on TMEJ for DSB repair. It is unknown whether deficiencies in other components of the DNA damage response (DDR) also result in Pol θ addiction. Here we use a CRISPR...
Paper Details
Title
Genetic determinants of cellular addiction to DNA polymerase theta
Published Date
Sep 19, 2019
Volume
10
Issue
1
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