The heterogeneous pathogenesis of type 1 diabetes mellitus
Abstract
Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic β-cells that is mediated by the immune system. Multiple genetic and environmental factors found in variable combinations in individual patients are involved in the development of T1DM. Genetic risk is defined by the presence of particular allele combinations, which in the major susceptibility locus (the HLA region) affect T cell recognition and tolerance to foreign and...
Paper Details
Title
The heterogeneous pathogenesis of type 1 diabetes mellitus
Published Date
Sep 18, 2019
Journal
Volume
15
Issue
11
Pages
635 - 650
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