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Nature Reviews Endocrinology
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#1Jorma Ilonen (TYKS: Turku University Hospital)H-Index: 67
#2Johanna Lempainen (TYKS: Turku University Hospital)H-Index: 12
Last.Riitta Veijola (OUH: Oulu University Hospital)H-Index: 2
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Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic β-cells that is mediated by the immune system. Multiple genetic and environmental factors found in variable combinations in individual patients are involved in the development of T1DM. Genetic risk is defined by the presence of particular allele combinations, which in the major susceptibility locus (the HLA region) affect T cell recognition and tolerance to foreign and autologous molecules. Multiple other loci also regula...
#1Sarah M. Turpin-Nolan (Monash University)
#2Michael Joseph Joyner (Mayo Clinic)H-Index: 58
Last.Mark A. Febbraio (Monash University)H-Index: 84
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Faecal microbiota transplantation (FMT) has been suggested to be a therapeutic strategy for inflammatory diseases and it is known that regular physical activity can alter the composition of the gut microbiota. Now, a study proposes that FMT might increase exercise performance in athletes, raising the possibility of ‘faecal doping’.
#1Naomi Dirckx (JHUSOM: Johns Hopkins University School of Medicine)
#2Megan C. Moorer (VA: United States Department of Veterans Affairs)H-Index: 1
Last.Ryan C. Riddle (VA: United States Department of Veterans Affairs)H-Index: 18
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Osteoblasts are specialized mesenchymal cells that synthesize bone matrix and coordinate the mineralization of the skeleton. These cells work in harmony with osteoclasts, which resorb bone, in a continuous cycle that occurs throughout life. The unique function of osteoblasts requires substantial amounts of energy production, particularly during states of new bone formation and remodelling. Over the last 15 years, studies have shown that osteoblasts secrete endocrine factors that integrate the me...
#1Olle Korsgren (Uppsala University)H-Index: 59
#2Jay S. Skyler (UM: University of Miami)H-Index: 57
Last.Johnny Ludvigsson (Linköping University)H-Index: 61
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For a person with type 1 diabetes mellitus, lifelong insulin treatment is the only therapeutic option. However, increased blood levels of glucose are just a symptom of impaired β-cell function. Approaching the centenary of the first insulin injection, broadening of international therapeutic guidelines to improve diagnostics, as well as monitor and preserve β-cell function, is warranted.
#1Wei Perng (Colorado School of Public Health)H-Index: 13
#2Emily Oken (Harvard University)H-Index: 58
A large registry-based study found that maternal overweight and obesity are associated with incident type 2 diabetes mellitus in offspring. The results align with those of prospective cohort studies and emphasize a need for interventions that target maternal weight during very early gestation, to optimize maternal and offspring health.
#1Charles Chapron (Paris V: Paris Descartes University)H-Index: 25
#2Louis Marcellin (Paris V: Paris Descartes University)H-Index: 14
Last.Pietro Santulli (Paris V: Paris Descartes University)H-Index: 17
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Endometriosis is a chronic inflammatory disease defined as the presence of endometrial tissue outside the uterus, which causes pelvic pain and infertility. This disease should be viewed as a public health problem with a major effect on the quality of life of women as well as being a substantial economic burden. In light of the considerable progress with diagnostic imaging (for example, transvaginal ultrasound and MRI), exploratory laparoscopy should no longer be used to diagnose endometriotic le...
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