Homomeric GluA2(R) AMPA receptors can conduct when desensitized
Abstract
Desensitization is a canonical property of ligand-gated ion channels, causing progressive current decline in the continued presence of agonist. AMPA-type glutamate receptors (AMPARs), which mediate fast excitatory signaling throughout the brain, exhibit profound desensitization. Recent cryo-EM studies of AMPAR assemblies show their ion channels to be closed in the desensitized state. Here we present evidence that homomeric Q/R-edited AMPARs...
Paper Details
Title
Homomeric GluA2(R) AMPA receptors can conduct when desensitized
Published Date
Sep 20, 2019
Journal
Volume
10
Issue
1
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