Peptides derived from rice α-globulin reduce atherosclerosis in apolipoprotein E-deficient mice by inhibiting TNF-α-induced vascular endothelial cells injury

Rice α-globulin has been reported to possess anti-atherosclerotic activity, but the key peptides in the rice α-globulin and the underlying mechanisms remain unknown. The anti-atherosclerotic effects of the rice α-globulin peptides YYGGEGSSSEQG and SESEM were observed in apolipoprotein E-deficient (ApoE−/−) mice in this study. The synthetic peptides were orally administered to ApoE−/− mice at a dose of 100 mg/kg body weight. The lesion area in...