Match!

Association of Laboratory Methods, Colonization Density, and Age With Detection of Streptococcus pneumoniae in the Nasopharynx

Published on Dec 31, 2019in American Journal of Epidemiology4.473
· DOI :10.1093/aje/kwz191
Catherine G. Sutcliffe21
Estimated H-index: 21
(Johns Hopkins University),
Lindsay Renee Grant14
Estimated H-index: 14
(Johns Hopkins University)
+ 10 AuthorsLaura L. Hammitt17
Estimated H-index: 17
(Johns Hopkins University)
Abstract
  • References (39)
  • Citations (0)
📖 Papers frequently viewed together
78% of Scinapse members use related papers. After signing in, all features are FREE.
References39
Newest
#2Juan DavidH-Index: 1
Introduccion: La meningits aguda bacteriana por Streptococcus pneumoniae es una patologia importante desde el punto de vista de salud publica por su alta morbimortalidad. Desde el ano 2006 se viene introduciendo la vacuna antineumococcica en el pais de forma progresiva, y en el ano 2012 se introduce en el esquema de vacunacion obligatorio. Su impacto sobre la epidemiologia de la enfermedad se ha venido estudiando en los ultimos anos. Objetivo: Realizar una caracterizacion clinica, epidemiologica...
439 CitationsSource
#1Susan C. MorpethH-Index: 20
#2Patrick K. Munywoki (Wellcome Trust)H-Index: 16
Last. J. Anthony G. Scott (University of Oxford)H-Index: 37
view all 9 authors...
Viral upper respiratory tract infection (URTI) predisposes to bacterial pneumonia possibly by facilitating growth of bacteria such as Streptococcus pneumoniae colonising the nasopharynx. We investigated whether viral URTI is temporally associated with an increase in nasopharyngeal pneumococcal concentration. Episodes of symptomatic RSV or rhinovirus URTI among children <5 years were identified from a longitudinal household study in rural Kenya. lytA and alu PCR were performed on nasopharyngeal s...
5 CitationsSource
#1Brian Wahl (Johns Hopkins University)H-Index: 3
#2Katherine L O'Brien (Johns Hopkins University)H-Index: 58
Last. Maria Deloria Knoll (Johns Hopkins University)H-Index: 21
view all 13 authors...
Summary Background Pneumococcal conjugate vaccine (PCV) and Haemophilus influenzae type b (Hib) vaccine are now used in most countries. To monitor global and regional progress towards improving child health and to inform national policies for disease prevention and treatment, we prepared global, regional, and national disease burden estimates for these pathogens in children from 2000 to 2015. Methods Using WHO and Maternal and Child Epidemiology Estimation collaboration country-specific estimate...
77 CitationsSource
#1Courtney P. Olwagen (University of the Witwatersrand)H-Index: 2
#2Peter V. Adrian (University of the Witwatersrand)H-Index: 28
Last. Shabir A. Madhi (National Health Laboratory Service)H-Index: 51
view all 3 authors...
S. pneumoniae is a common colonizer of the human nasopharynx in high income and low-middle income countries. Due to limitations of standard culture methods, the prevalence of concurrent colonization with multiple serotypes is unclear. We evaluated the use of multiplex quantitative PCR (qPCR) to detect multiple pneumococcal serotypes/group colonization in archived nasopharyngeal swabs of pneumococcal conjugate vaccine naive children who had previously been investigated by traditional culture meth...
5 CitationsSource
#1Leigh M. Howard (Vandy: Vanderbilt University)H-Index: 7
#2Roger R. FanH-Index: 2
Last. Carlos G. Grijalva (Vandy: Vanderbilt University)H-Index: 38
view all 12 authors...
Indoor smoke exposure is common in developing countries and may influence nasopharyngeal (NP) pneumococcal colonization density and risk of acute respiratory illness. We compared colonization density among Andean children living in households previously enrolled in a randomized controlled trial of a home intervention package including improved stoves to reduce smoke, kitchen sinks, and water disinfection.; We enrolled 260 children aged <3 years and made weekly household visits to assess for acut...
5 CitationsSource
#1Henry C. Baggett (CDC: Centers for Disease Control and Prevention)H-Index: 24
#2Nora L. WatsonH-Index: 9
Last. J. L. MitchellH-Index: 15
view all 77 authors...
Previous studies suggested an association between upper airway pneumococcal colonization density and pneumococcal pneumonia, but data in children are limited. Using data from the Pneumonia Etiology Research for Child Health (PERCH) study, we assessed this potential association.PERCH is a case-control study in 7 countries: Bangladesh, The Gambia, Kenya, Mali, South Africa, Thailand, and Zambia. Cases were children aged 1-59 months hospitalized with World Health Organization-defined severe or very...
21 CitationsSource
#1Ron Dagan (BGU: Ben-Gurion University of the Negev)H-Index: 80
#2Christine Juergens (Pfizer)H-Index: 11
Last. Daniel A. Scott (Pfizer)H-Index: 29
view all 9 authors...
Abstract Background In addition to reducing vaccine-type nasopharyngeal carriage rates, pneumococcal conjugate vaccines (PCVs) may decrease carriage density in vaccinated individuals still carrying vaccine serotypes. However, reduction of carriage density has not been systematically studied. This study compared the effect of PCV13 versus PCV7 on carriage density of the serotypes in PCV13 that are not included in PCV7. Methods This randomized, double-blind study was conducted in southern Israel a...
5 CitationsSource
#1Roger R. FanH-Index: 2
#2Leigh M. HowardH-Index: 7
Last. Carlos G. GrijalvaH-Index: 38
view all 11 authors...
We examined nasopharyngeal pneumococcal colonization density patterns surrounding acute respiratory illnesses (ARI) in young children in Peru. Pneumococcal densities were dynamic, gradually increasing leading up to an ARI, peaking during the ARI, and decreasing after the ARI. Rhinovirus co-infection was associated with higher pneumococcal densities.
20 CitationsSource
#1Lindsay Renee Grant (Johns Hopkins University)H-Index: 14
#2Laura L. Hammitt (Johns Hopkins University)H-Index: 17
Last. Katherine L O'Brien (Johns Hopkins University)H-Index: 58
view all 9 authors...
Background:Community-wide impact of pneumococcal conjugate vaccines (PCV) is conferred by reductions in vaccine-type nasopharyngeal carriage. We evaluated the impact of PCV13 on carriage of PCV13-specific types (1, 3, 5, 6A, 7F and 19A) and 6C among American Indians.Methods:A nasopharyngeal specimen
19 CitationsSource
#1Grant Mackenzie (Medical Research Council)H-Index: 13
#2Philip C. Hill (University of Otago)H-Index: 44
Last. Tumani Corrah (Medical Research Council)H-Index: 45
view all 42 authors...
Summary Background Little information is available about the effect of pneumococcal conjugate vaccines (PCVs) in low-income countries. We measured the effect of these vaccines on invasive pneumococcal disease in The Gambia where the 7-valent vaccine (PCV7) was introduced in August, 2009, followed by the 13-valent vaccine (PCV13) in May, 2011. Methods We conducted population-based surveillance for invasive pneumococcal disease in individuals aged 2 months and older who were residents of the Basse...
63 CitationsSource
Cited By0
Newest