Venous return and the physical connection between distribution of segmental pressures and volumes

More than sixty years ago, Guyton and coworkers related their observations of venous return to a mathematical model. Showing steady-state flow (F) as proportional to the difference between mean systemic pressure (Pms) and right atrial pressure (Pra), the model fit their data. The parameter defined by the ratio (Pms − Pra)/F, first called an “impedance,” came to be called the “resistance to venous return.” The interpretation that Pra opposes Pms...