Estimated Risk for a Second Malignancy after Proton and Photon Radiation Therapy for Breast Cancer

Approximately 10% of all second cancers among breast cancer patients are attributable to radiation exposure. In the era of proton therapy, we hypothesized that proton beam radiation may have the potential to confer a lower risk of second malignancy compared to photon radiation. Therefore, the purpose of this study is to compare the estimated second malignancy risks of modern proton and photon therapy techniques for locally advanced breast...