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Nicolas Depauw
Harvard University
RadiologyPencil-beam scanningProton therapyNuclear medicineMedicine
71Publications
12H-index
664Citations
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Publications 72
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#1Nicolas Depauw (Harvard University)H-Index: 12
#2Jani Keyriläinen (TYKS: Turku University Hospital)H-Index: 18
Last. Hanne M. Kooy (Harvard University)H-Index: 43
view all 7 authors...
Abstract Purpose Treatment planning for proton therapy requires the relative proton stopping power ratio (RSP) information of the patient for accurate dose calculations. RSP are conventionally obtained after mapping of the Hounsfield units (HU) from a calibrated patient computed tomography (CT). One or multiple CT are needed for a given treatment which represents additional, undesired dose to the patient. For prostate cancer, magnetic resonance imaging (MRI) scans are the gold standard for segme...
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#1Rachel B. Jimenez (Harvard University)H-Index: 11
#2Shea Hickey (Harvard University)H-Index: 2
Last. Shannon M. MacDonald (Harvard University)H-Index: 35
view all 18 authors...
PURPOSETo evaluate the safety and efficacy of proton beam radiation therapy (RT) for patients with breast cancer who require regional nodal irradiation.METHODSPatients with nonmetastatic breast can...
1 CitationsSource
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#1Olga Hamming-Vrieze (NKI-AVL: Netherlands Cancer Institute)H-Index: 15
#2Nicolas Depauw (Harvard University)H-Index: 12
Last. Hanne M. Kooy (Harvard University)H-Index: 43
view all 8 authors...
Setup and range uncertainties compromise radiotherapy plan robustness. We introduce a method to evaluate the clinical effect of these uncertainties on the population using tumor control probability (TCP) and normal tissue complication probability (NTCP) models. Eighteen oropharyngeal cancer patients treated with curative intent were retrospectively included. Both photon (VMAT) and proton (IMPT) plans were created using a planning target volume as planning objective. Plans were recalculated for u...
1 CitationsSource
#1E. BatinH-Index: 3
#2Nicolas DepauwH-Index: 12
Last. Rachel B. JimenezH-Index: 11
view all 4 authors...
Source
#1A.C. Kraan (INFN: Istituto Nazionale di Fisica Nucleare)H-Index: 4
#2Nicolas Depauw (Harvard University)H-Index: 12
Last. Hanne M. Kooy (Harvard University)H-Index: 43
view all 5 authors...
Abstract Background In scanned proton beam therapy systematic deviations in spot size at iso-center can occur as a result of changes in the beam-line optics. There is currently no general guideline of the spot size accuracy required clinically. In this work we quantify treatment plan robustness to systematic spot size variations as a function of spot size and spot spacing, and we suggest guidelines for tolerance levels for spot size variations. Methods Through perturbation of spot size in treatm...
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#1E. Batin (Harvard University)H-Index: 3
#2Nicolas Depauw (Harvard University)H-Index: 12
Last. Hsiao-Ming Lu (Harvard University)H-Index: 27
view all 5 authors...
Abstract Purpose Proton postmastectomy radiation therapy (PMRT) patients are positioned daily using surface imaging with additional x-ray imaging for confirmation. This study aims to investigate whether weekly x-ray imaging with daily surface imaging, as performed for photon treatment, is sufficient to maintain PMRT patient positioning fidelity. Methods and materials Calculated radiographic corrections and surface imaging residual setup errors were analyzed at the treatment angle for 28 PMRT pat...
1 CitationsSource
#1Rachel B. JimenezH-Index: 11
#2Beow Y. YeapH-Index: 64
Last. Shannon M. MacDonaldH-Index: 35
view all 8 authors...
Source
#1A.C. Kraan (INFN: Istituto Nazionale di Fisica Nucleare)H-Index: 4
#2Nicolas Depauw (Harvard University)H-Index: 12
Last. Hanne M. Kooy (Harvard University)H-Index: 43
view all 6 authors...
Background Spot size σ (in air at isocenter), interspot spacing d, and spot charge q influence dose delivery efficiency and plan quality in Intensity Modulated Proton Therapy (IMPT) treatment planning. The choice and range of parameters varies among different manufacturers. The goal of this work is to demonstrate the influence of the spot parameters on dose quality and delivery in IMPT treatment plans, to show their interdependence, and to make practitioners aware of the spot parameter values fo...
4 CitationsSource
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