Serum Neurofilament Light Chain Levels in Patients With Presymptomatic Multiple Sclerosis

Importance

Unrecognized demyelinating events often precede the clinical onset of multiple sclerosis (MS). Identification of these events at the time of occurrence would have implications for early diagnosis and the search of causal factors for the disease.

Objective

To assess whether serum neurofilament light chain (sNfL) levels are elevated before the clinical MS onset.

Design, Setting, and Participants

Nested...