Alberto Ascherio
Harvard University
Publications 462
#1Patrick Kearns (Edin.: University of Edinburgh)H-Index: 1
#2Martin Paton (NHS Scotland)
Last.Belinda Weller (Edin.: University of Edinburgh)H-Index: 2
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Background Fifteen regional studies published over the last six decades surveying prevalence, mortality and hospital admissions have suggested that Scotland is amongst the highest risk nations for multiple sclerosis (MS) in the world. However, substantial intranational variation in rates (between regions) has been described in numerous countries, including in the only previous Scottish national survey, which used hospital admission data, to address this issue. Against this backdrop, the Scottish...
#1Kjetil Bjørnevik (Harvard University)H-Index: 9
#2Karl Münger (Harvard University)H-Index: 66
Last.Alberto Ascherio (Harvard University)H-Index: 116
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Importance Unrecognized demyelinating events often precede the clinical onset of multiple sclerosis (MS). Identification of these events at the time of occurrence would have implications for early diagnosis and the search of causal factors for the disease. Objective To assess whether serum neurofilament light chain (sNfL) levels are elevated before the clinical MS onset. Design, Setting, and Participants Nested case-control study among US military personnel who have serum samples stored in the U...
#2Eric A. MacklinH-Index: 35
Last.David S. RussellH-Index: 27
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Objective To investigate whether women and men with Parkinson disease (PD) differ in their biochemical and clinical responses to long-term treatment with inosine. Methods The Safety of Urate Elevation in Parkinson’s Disease (SURE-PD) trial enrolled 75 people with early PD and baseline serum urate below 6 mg/dL and randomized them to 3 double-blinded treatment arms: oral placebo or inosine titrated to produce mild (6.1–7.0 mg/dL) or moderate (7.1–8.0 mg/dL) serum urate elevation for up to 2 years...
#1Karl Münger (Harvard University)H-Index: 66
#2Kira Hongell (TYKS: Turku University Hospital)H-Index: 2
Last.Alberto Ascherio (Harvard University)H-Index: 116
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#1Marianna CorteseH-Index: 6
#2Tanuja ChitnisH-Index: 46
Last.Karl MüngerH-Index: 66
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Objective To investigate the association between mineral intake (potassium, magnesium, calcium, phosphorus, iron, zinc, manganese, copper) and multiple sclerosis (MS) risk. Methods In a prospective cohort study, we assessed dietary and supplemental mineral intake by a validated food frequency questionnaire administered every 4 years to 80,920 nurses in the Nurses9 Health Study (1984–2002) and 94,511 in the Nurses9 Health Study II (1991–2007). There were 479 new MS cases during follow-up. We esti...
#1Rachit Bakshi (Harvard University)H-Index: 9
#2Eric A. Macklin (Harvard University)H-Index: 35
Last.Michael A. Schwarzschild (Harvard University)H-Index: 66
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Objective To identify prediagnostic plasma metabolomic biomarkers associated with amyotrophic lateral sclerosis (ALS). Methods We conducted a global metabolomic study using a nested case-control study design within 5 prospective cohorts and identified 275 individuals who developed ALS during follow-up. We profiled plasma metabolites using liquid chromatography–mass spectrometry and identified 404 known metabolites. We used conditional logistic regression to evaluate the associations between meta...