Enantioselective Alkylation of 2-Alkylpyridines Controlled by Organolithium Aggregation
Volume: 141, Issue: 38, Pages: 15024 - 15028
Published: Aug 28, 2019
Abstract
Direct enantioselective α-alkylation of 2-alkylpyridines provides access to chiral pyridines via an operationally simple protocol that obviates the need for prefunctionalization or preactivation of the substrate. The alkylation is accomplished using chiral lithium amides as noncovalent stereodirecting auxiliaries. Crystallographic and solution NMR studies provide insight into the structure of well-defined chiral aggregates in which a lithium...
Paper Details
Title
Enantioselective Alkylation of 2-Alkylpyridines Controlled by Organolithium Aggregation
Published Date
Aug 28, 2019
Volume
141
Issue
38
Pages
15024 - 15028
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