Review paper
Toward in silico Identification of Tumor Neoantigens in Immunotherapy
Abstract
Identification of tumor neoantigens has been facilitated by development of in silico methods or tools using high-throughput sequencing data. Neoantigens derived from single nucleotide variants (SNVs) and small insertions and deletions (INDELs) have been well-characterized in recent studies. Mutations derived from RNA editing, alternative splicing, and alleged noncoding regions have been demonstrated to generate neoantigens. Cancer immunotherapy...
Paper Details
Title
Toward in silico Identification of Tumor Neoantigens in Immunotherapy
Published Date
Nov 1, 2019
Journal
Volume
25
Issue
11
Pages
980 - 992
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History