Therapeutic effect of deferrioxamine conjugated to PEGylated gold nanoparticles and complexed with Mn(II) beside the CT scan and MRI diagnostic studies

Synthesis, characterization, and in-vitro/in-vivo examinations of a theranostic system with novel formulation and straightforward synthesis method are reported in this work. Deferrioxamine-manganese(II), as a theranostic complex (Deferrioxamine as therapeutic and manganese(II) as MRI imaging agent) is conjugated in adjacent to folic acid with the PEGylated gold nanoparticles, leading to formation of biodegradable and biocompatible...