Frontline Science: A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling
Abstract
β2 integrins are the main adhesion molecules in neutrophils and other leukocytes and are rapidly activated by inside-out signaling, which results in conformational changes that are transmitted through the transmembrane domain (TMD). Here, we investigated the biologic effect of introducing a proline mutation in the β2 integrin TMD to create a flexible kink that uncouples the topology of the inner half of the TMD from the outer half and impairs...
Paper Details
Title
Frontline Science: A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling
Published Date
Sep 1, 2019
Journal
Volume
107
Issue
2
Pages
175 - 183
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