SIRT2: Controversy and multiple roles in disease and physiology
Abstract
Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is predominantly found in the cytoplasm but is also found in the mitochondria and in the nucleus. Recently, accumulating evidence has uncovered a growing number of substrates and additional detailed functions of SIRT2 in a wide range of biological processes, marking its crucial role. Here, we...
Paper Details
Title
SIRT2: Controversy and multiple roles in disease and physiology
Published Date
Nov 1, 2019
Journal
Volume
55
Pages
100961 - 100961
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