Ageing Research Reviews
Papers 1141
1 page of 115 pages (1,141 results)
#1Alexander Fedintsev (RAS: Russian Academy of Sciences)H-Index: 3
#2Alexey Moskalev (RAS: Russian Academy of Sciences)H-Index: 25
Damage accumulation in long-living macromolecules (especially extracellular matrix (ECM) proteins, nuclear pore complex (NPC) proteins, and histones) is a missing hallmark of aging. Stochastic non-enzymatic modifications of ECM trigger cellular senescence as well as many other hallmarks of aging affect organ barriers integrity and drive tissue fibrosis. The importance of it for aging makes it a key target for interventions. The most promising of them can be AGE inhibitors (chelators, O-acetyl gr...
#1Abram Giller (University of Haifa)H-Index: 1
#2Mariana Andrawus (University of Haifa)
Last. Gil Atzmon (University of Haifa)H-Index: 47
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Abstract The process of aging can be defined as the sum accumulation of damages and changes in metabolism during the life of an organism, due to both genetic predisposition and stochastic damage. During the gestational period and following parturition, similar damage can be seen due to the strenuous effect on the maternal body, exhibited on both the physiological and cellular level. In this review, we will focus on the similar physiological and cellular characteristics exhibited during pregnancy...
#1Salvatore Collura (UNIBO: University of Bologna)H-Index: 1
#2Cristina Morsiani (UNIBO: University of Bologna)H-Index: 7
Last. Mauro Gargiulo (UNIBO: University of Bologna)H-Index: 21
view all 11 authors...
Abstract Atherosclerosis is considered a chronic inflammatory disease of arteries associated with the aging process. Many risk factors have been identified and they are mainly related to life-styles, gene-environment interactions and socioeconomic status. Carotid and coronary artery diseases are the two major atherosclerotic conditions, being the primary cause of stroke and heart attack, respectively. Nevertheless, carotid plaque assumes particular aspects not only for the specific molecular mec...
#1Pedro L. Valenzuela (University of Alcalá)H-Index: 8
#2Javier S. Morales (UEM: European University of Madrid)H-Index: 5
Last. Alejandro Lucia (UEM: European University of Madrid)H-Index: 61
view all 8 authors...
Abstract Background Acute hospitalisation can have adverse effects in older adults, notably functional decline. We aimed to summarize evidence on the effects of exercise interventions in acutely hospitalised older adults. Methods Relevant articles were systematically searched (PubMed, Web of Science, Rehabilitation & Sports Medicine Source, and EMBASE) until 19th March 2020. Randomized controlled trials (RCTs) of in-hospital exercise interventions versus usual care conducted in older adults (>60...
#2Alessandro Di MinnoH-Index: 16
Last. Mauro PepiH-Index: 45
view all 12 authors...
Aging of the aortic valve, characterized by leaflet thickening and loss of extensibility, leads to progressive changes in valve function. These age-related mechanisms have not been evaluated yet in sex-specific calcific aortic valve stenosis (CAVS) onset and progression. Recent studies reported the association between high aortic valve calcification (AVC) load and male gender in patients with CAVS while women present faster progression than men. To evaluate these age- and sex-specific difference...
#1Sara M. Romanella (UNISI: University of Siena)
#2Daniel Roe (BIDMC: Beth Israel Deaconess Medical Center)
Last. Emiliano Santarnecchi (UNISI: University of Siena)H-Index: 22
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Abstract As we age, sleep patterns undergo severe modifications of their micro and macrostructure, with an overall lighter and more fragmented sleep structure. In general, interventions targeting sleep represent an excellent opportunity not only to maintain life quality in the healthy aging population, but also to enhance cognitive performance and, when pathology arises, to potentially prevent/slow down conversion from e.g. Mild Cognitive Impairment (MCI) to Alzheimer’s Disease (AD). Sleep abnor...
#1Giulia Matacchione (Marche Polytechnic University)H-Index: 4
#2Felicia Gurau (Marche Polytechnic University)
Last. Massimiliano Bonafè (UNIBO: University of Bologna)H-Index: 58
view all 14 authors...
Epidemiological evidence from observational studies suggests that dietary polyphenols (PPs) - phytochemicals found in a variety of plant-based foods - can reduce the risk of developing type 2 diabetes mellitus (T2DM). Clinical trials have also indicated that PPs may help manage the two key features of T2DM, hyperglycemia and dyslipidemia. Since the incidence of T2DM is dramatically increasing worldwide, identifying food-based approaches that can reduce the risk of developing it and help manage i...
1 CitationsSource
#1Vladimir Heiskanen (UH: University of Helsinki)H-Index: 3
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Abstract Both sun exposure and serum vitamin D levels have been associated with lower risks of all-cause mortality and chronic age-related diseases, e.g., cancer, diabetes and cardiovascular disease, in epidemiological studies. These associations have mainly been ascribed to beneficial effects of vitamin D. However, a vast body of randomized controlled trials (RCTs) and Mendelian randomization studies have failed to confirm any major health benefits from vitamin D supplementation. In this review...
#1Davin Lee (DGIST: Daegu Gyeongbuk Institute of Science and Technology)
#2Yoon Ha Choi (DGIST: Daegu Gyeongbuk Institute of Science and Technology)H-Index: 1
Last. Sung Bae Lee (DGIST: Daegu Gyeongbuk Institute of Science and Technology)H-Index: 13
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Abstract Treatment options for many neurodegenerative diseases are limited due to the lack of early diagnostic procedures that allow timely delivery of therapeutic agents to affected neurons prior to cell death. While notable advances have been made in neurodegenerative disease biomarkers, whether or not the biomarkers discovered to date are useful for early diagnosis remains an open question. Additionally, the reliability of these biomarkers has been disappointing, due in part to the large diss...
#1Alberto Pilotto (University of Bari)H-Index: 55
#2Carlo Custodero (University of Bari)H-Index: 4
Last. Luigi Ferruci (NIH: National Institutes of Health)H-Index: 133
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Frailty is an important factor determining a higher risk of adverse health outcomes in older adults. Although scientific community in the last two decades put a lot of effort for its definition, to date no consensus was reached on its assessment. The mainstream thinking describes frailty as a loss of physical functions or as accumulation of multiple deficits. Recently, a novel conceptual model of frailty has emerged based on the loss of harmonic interaction between multiple domains (also referre...
3 CitationsSource
Top fields of study
Diabetes mellitus
Cell biology