Alcohol septal ablation in patients with severe septal hypertrophy

Published on Aug 30, 2019in Heart5.082
· DOI :10.1136/heartjnl-2019-315422
Josef Veselka22
Estimated H-index: 22
(Charles University in Prague),
Morten Søndergaard Jensen12
Estimated H-index: 12
(UCPH: University of Copenhagen)
+ 11 AuthorsLothar Faber31
Estimated H-index: 31
(RUB: Ruhr University Bochum)
Objective The current guidelines suggest alcohol septal ablation (ASA) is less effective in hypertrophic obstructive cardiomyopathy (HOCM) patients with severe left ventricular hypertrophy, despite acknowledging that systematic data are lacking. Therefore, we analysed patients in the Euro-ASA registry to test this statement. Methods We compared the short-term and long-term outcomes of patients with basal interventricular septum (IVS) thickness Results A total of 1519 patients (57±14 years, 49% women) with symptomatic HOCM were treated, including 67 (4.4%) patients with IVS thickness ≥30 mm. The occurrence of short-term major adverse events were similar in both groups. The mean follow-up was 5.4±4.3 years and 5.1±4.1 years, and the all-cause mortality rate was 2.57 and 2.94 deaths per 100 person-years of follow-up in the IVS Conclusions The short-term results and the long-term relief of dyspnoea, residual left ventricular outflow obstruction and occurrence of repeated septal reduction procedures in patients with basal IVS ≥30 mm is similar to those with IVS
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