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Heart
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Papers 26138
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#1Clément BrietH-Index: 1
#2Katrien BlanchartH-Index: 4
Last.Farzin BeyguiH-Index: 38
view all 11 authors...
Objective We investigated whether mental status assessed by simple bedside tests in elderly patients admitted for acute coronary syndromes (ACS) was associated with higher risk of mortality. Methods We used the data from a prospective, open, ongoing cohort of patients≥75 years old admitted for ACS to a tertiary centre. Cognitive impairment (CogI) was defined by delirium detected by the Confusion Assessment Method or an abnormal Mini Mental State Examination score. A Cox model adjusted on predefi...
2 CitationsSource
#1Catherine M. Otto (UW: University of Washington)H-Index: 70
Patient-reported outcome measures (PROMs) now are recognised as an essential element in clinical cardiovascular research studies. In addition, we are increasing aware of significant sex differences, not only in risk factors, clinical presentation and outcomes, but in the treatments provided to patients with cardiovascular disease. In this issue of Heart , a study by Gleason and colleagues1 compared atrial fibrillation (AF) therapy and PROMs in women versus men in a cohort of 953 AF patients (mea...
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#1Philip D. AdamsonH-Index: 15
#2David A. McAllisterH-Index: 29
Last.A. Mark Richards (University of Otago)H-Index: 68
view all 14 authors...
Objectives High-sensitivity cardiac troponin testing is used in the diagnosis of acute coronary syndromes but its role during convalescence is unknown. We investigated the long-term prognostic significance of serial convalescent high-sensitivity cardiac troponin concentrations following acute coronary syndrome. Methods In a prospective multicentre observational cohort study of 2140 patients with acute coronary syndrome, cardiac troponin I concentrations were measured in 1776 patients at 4 and 12...
1 CitationsSource
#1Rong Bing (Edin.: University of Edinburgh)H-Index: 2
#2James Henderson I (Edin.: University of Edinburgh)H-Index: 22
Last.Philip D. AdamsonH-Index: 15
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Objective Troponin and B-type natriuretic peptide (BNP) concentrations are associated with cardiovascular risk in stable patients. Understanding their determinants and identifying modifiable clinical targets may improve outcomes. We aimed to establish clinical and cardiac determinants of these biomarkers. Methods This was a prespecified substudy from the randomised Scottish Computed Tomography of the Heart trial, which enrolled patients 18–75 years with suspected stable angina between 2010 and 2...
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#1Roel L. F. van der Palen (LUMC: Leiden University Medical Center)H-Index: 5
#2Teun van der Bom (UvA: University of Amsterdam)H-Index: 1
Last.Nico A. Blom (UvA: University of Amsterdam)H-Index: 5
view all 14 authors...
Objective To study neo-aortic growth and the evolution of neo-aortic valve regurgitation (AR) in patients with transposition of the great arteries (TGA) after arterial switch operation (ASO) from newborn to adulthood and to identify patients at risk. Methods Neo-aortic dimensions (annulus/root/sinotubular junction) and neo-aortic valve regurgitation were assessed serially in 345 patients with TGA who underwent ASO between 1977 and 2015. Linear mixed-effect models were used to assess increase of ...
1 CitationsSource
#1Samantha K. Atkins (Brigham and Women's Hospital)H-Index: 4
#2Elena Aikawa (Center for Excellence in Education)H-Index: 64
Performing basic translational research to elucidate the underlying mechanisms driving calcific aortic valve disease (CAVD) pathogenesis is a critical step for the development of early intervention strategies. CAVD is a significant worldwide healthcare burden that is increased in ageing populations, and currently no therapies exist to delay or prevent its onset and progression. In their Heart paper, Gomez-Stallons et al histologically present the progression of calcification and associated matri...
1 CitationsSource
#1Eva Gerdts (University of Bergen)H-Index: 40
#2Sahrai SaeedH-Index: 5
Last.Richard B. Devereux (Cornell University)H-Index: 134
view all 8 authors...
Objective Whether increased myocardial oxygen demand could help explain the association of left ventricular (LV) hypertrophy with higher adverse event rate in patients with aortic valve stenosis (AS) is unknown. Methods Data from 1522 patients with asymptomatic mostly moderate AS participating in the Simvastatin-Ezetimibe in AS study followed for a median of 4.3 years was used. High LV mass–wall stress–heart rate product was identified as >upper 95% CI limit in normal subjects. The association o...
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#1Peter A. Kavsak (McMaster University)H-Index: 26
#2Philip J. Devereaux (McMaster University)H-Index: 74
High-sensitivity cardiac troponin testing has received much hype over the last decade. Substantial focus on high-sensitivity cardiac troponin testing has occurred due to the combination of diagnostic company marketing, different labelling requirements across regulatory bodies and investigators and journals using different terminology.1 There is a need for agreement on what constitutes a high-sensitivity cardiac troponin assay.1 2 This is not a trivial point, as publications in influential journa...
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#2Antony French (RUH: Royal United Hospital)H-Index: 1
Diagnostic pathways for identification of clinically significant paroxysmal arrhythmia have historically relied on ambulatory ECG monitoring. While useful as a risk stratification tool in certain patient groups, in general, it has a limited yield for infrequent arrhythmia. This is inherently cost-inefficient, and time to diagnosis can be delayed. Smartphone-based ECG devices are now well established in the public market. However, their adoption into standard investigatory pathways is not yet wid...
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#1Jonathan Buber (UW: University of Washington)H-Index: 10
#2Keri M. ShaferH-Index: 8
### Learning objectives Malcolm is a 35-year-old patient followed at a safety net hospital. He describes growing up with limited resources both in his family and at his school. As the child of a single mother, his afternoons were often spent hanging out in his neighbourhood. He recalls that there were two options ‘basketball or gangs’. Because of his complex congenital heart disease, he was not allowed to play sports and his exercise capacity was never evaluated. Now, 20 years later, he feels th...
1 CitationsSource
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