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#1Catherine M. Otto (UW: University of Washington)H-Index: 70
The use of implantable cardiac defibrillators (ICDs) has dramatically improved outcomes for patients with many types of heart disease. Yet, the patient with an ICD faces a difficult decision near the end of life—should the ICD be deactivated and, if so, when? Evidence to support a specific approach to this clinical dilemma is not amenable to standard research approaches because the outcomes are qualitative, not quantitative. Thus, carefully designed and implemented qualitative research studies a...
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Clinical introduction A 63-year-old woman recently diagnosed with lung metastasis, after routine chest radiography, was admitted to our hospital for unspecified symptoms, such as dyspnoea on minimal exertion and dry cough. Physical examination showed uncommon signs. The electrocardiogram showed sinus rhythm and incomplete left bundle branch block. Thoracic CT scan revealed bilateral lung and pleural metastases and pelvic CT showed a right femoral bone mass. Transthoracic echocardiography reveale...
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#1Brett J. Carroll (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 4
#2Mark L. Schermerhorn (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 44
Last.Warren J. Manning (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 91
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Acute aortic syndromes (AAS) represent a spectrum of disorders with a common theme of disruption in aortic integrity. AAS are associated with high morbidity and mortality and warrant emergent medical or surgical intervention as delayed treatment is associated with worse outcomes. There are multiple advanced imaging modalities for the diagnosis and complimentary assessment of AAS, each with advantages and limitations. CT angiography remains the imaging modality of choice for diagnosis in the over...
1 CitationsSource
#1J R Arnold (University of Leicester)H-Index: 1
#2Gerry P. McCann (University of Leicester)H-Index: 23
Cardiovascular magnetic resonance (CMR) is a rapidly evolving non-invasive imaging modality offering comprehensive, multiparametric assessment of cardiac structure and function in a variety of clinical situations. Cine imaging with CMR is the gold standard non-invasive imaging technique for the quantification of ventricular volumes and systolic function. It also affords superior visualisation of apical and right ventricular morphological abnormalities. In coronary artery disease, CMR stress perf...
1 CitationsSource
Approximately 2%–3% of patients with heart failure (HF) will sustain a stroke; an outcome considered by many to be worse than death.1 Not only are these events twofold to threefold more common in patients with HF, over half of the strokes are life-threatening or severely disabling2 and compared with the general population are associated with longer hospital stays and higher rates of mortality.3 Although atrial fibrillation (AF) and HF are linked and frequently coexist, HF has been increasingly r...
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#1Timothy C. Tan (Harvard University)H-Index: 19
Last.Xin Zeng (Harvard University)H-Index: 32
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Objective Cardioembolic (CE) stroke carries significant morbidity and mortality. Left atrial (LA) size has been associated with CE risk. We hypothesised that differential LA remodelling impacts on pathophysiological mechanism of major CE strokes. Methods A cohort of consecutive patients hospitalised with ischaemic stroke, classified into CE versus non-CE strokes using the Causative Classification System for Ischaemic Stroke were enrolled. LA shape and remodelling was characterised by assessing d...
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#1Jiapeng Lu (Peking Union Medical College)H-Index: 6
#2Lihua Zhang (Peking Union Medical College)H-Index: 3
Last.Harlan M. Krumholz (Yale University)H-Index: 170
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Objective We aimed to estimate the current use of secondary prevention drugs and identify its associated individual characteristics among those with established cardiovascular diseases (CVDs) in the communities of China. Methods We studied 2 613 035 participants aged 35–75 years from 8577 communities in 31 provinces in the China Patient-Centered Evaluative Assessment of Cardiac Events Million Persons Project, a government-funded public health programme conducted from 2014 to 2018. Participants s...
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#1Massimo ImazioH-Index: 45
Last.Gaetano M. De FerrariH-Index: 39
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Neoplastic pericardial effusion is a common and serious manifestation of advanced malignancies. Lung and breast carcinoma, haematological malignancies, and gastrointestinal cancer are the most common types of cancer involving the pericardium. Pericardial involvement in neoplasia may arise from several different pathophysiological mechanisms and may be manifested by pericardial effusion with or without tamponade, effusive-constrictive pericarditis and constrictive pericarditis. Management of thes...
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#1Jason R. Sims (Mayo Clinic)H-Index: 2
#2Guy S. Reeder (Mayo Clinic)H-Index: 62
Last.Mackram F. Eleid (Mayo Clinic)H-Index: 23
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Objective A subset of patients at the time of transcatheter mitral valve repair (TMVR) will have normal left atrial pressure (LAP) ( Methods A single-centre retrospective cohort of consecutive patients who underwent transcatheter edge-to-edge mitral valve clip and continuous LAP monitoring between 5/1/2014 and 5/1/2018 was analysed. One-year mortality was compared by Kaplan–Meier survival curves. Multivariable analysis was performed to identify predictors of normal LAP and 1 year mortality. Resu...
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#1Achintya Dinesh Singh (Cleveland Clinic)
#2Agrima Mian (Cleveland Clinic)
Last.Ganesan Karthikeyan (AIIMS: All India Institute of Medical Sciences)H-Index: 34
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Aim Patients with severe mitral stenosis (MS) and their clinicians typically choose percutaneous transvenous mitral commissurotomy (PTMC) over surgical commissurotomy (SC). However, the durability of PTMC relative to SC is uncertain. We compared the efficacy, safety and durability of PTMC with SC for the treatment of MS. Methods We searched EMBASE, MEDLINE and WHO ICTRP registers for randomised controlled trials (RCTs) comparing PTMC, and open and/or closed mitral commissurotomy. The principal o...
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