Original paper
A high-resolution map of non-crossover events reveals impacts of genetic diversity on mammalian meiotic recombination
Abstract
During meiotic recombination, homologue-templated repair of programmed DNA double-strand breaks (DSBs) produces relatively few crossovers and many difficult-to-detect non-crossovers. By intercrossing two diverged mouse subspecies over five generations and deep-sequencing 119 offspring, we detect thousands of crossover and non-crossover events genome-wide with unprecedented power and spatial resolution. We find that both crossovers and...
Paper Details
Title
A high-resolution map of non-crossover events reveals impacts of genetic diversity on mammalian meiotic recombination
Published Date
Aug 29, 2019
Journal
Volume
10
Issue
1
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Notes
History