Abdominal adiposity and cardiometabolic risk factors in children and adolescents: a Mendelian randomization analysis

Mendelian randomization studies in adults suggest that abdominal adiposity is causally associated with increased risk of type 2 diabetes and coronary artery disease in adults, but its causal effect on cardiometabolic risk in children remains unclear. We aimed to study the causal relation of abdominal adiposity with cardiometabolic risk factors in children by applying Mendelian randomization. We constructed a genetic risk score (GRS) using...