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Abdominal adiposity and cardiometabolic risk factors in children and adolescents: a Mendelian randomization analysis

Published on Nov 1, 2019in The American Journal of Clinical Nutrition6.568
· DOI :10.1093/ajcn/nqz187
Anna Viitasalo11
Estimated H-index: 11
(UCPH: University of Copenhagen),
Theresia M. Schnurr5
Estimated H-index: 5
(UCPH: University of Copenhagen)
+ 20 AuthorsTuomas O. Kilpelaeinen33
Estimated H-index: 33
(UCPH: University of Copenhagen)
Abstract
  • References (47)
  • Citations (0)
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References47
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#1Sara L. Pulit (University of Oxford)H-Index: 18
#2Charli E Stoneman (University of Exeter)H-Index: 2
Last. Cecilia M. Lindgren (University of Oxford)H-Index: 89
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More than one in three adults worldwide is either overweight or obese. Epidemiological studies indicate that the location and distribution of excess fat, rather than general adiposity, are more informative for predicting risk of obesity sequelae, including cardiometabolic disease and cancer. We performed a genome-wide association study meta-analysis of body fat distribution, measured by waist-to-hip ratio (WHR) adjusted for body mass index (WHRadjBMI), and identified 463 signals in 346 loci. Her...
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#1Anne-Sofie Graae (UCPH: University of Copenhagen)H-Index: 2
#2Mette Hollensted (UCPH: University of Copenhagen)H-Index: 8
Last. Torben Hansen (UCPH: University of Copenhagen)H-Index: 85
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Aims/hypothesis A genetic risk score (GRS) consisting of 53 insulin resistance variants (GRS53) was recently demonstrated to associate with insulin resistance in adults. We speculated that the GRS53 might already associate with insulin resistance during childhood, and we therefore aimed to investigate this in populations of Danish children and adolescents. Furthermore, we aimed to address whether the GRS associates with components of the metabolic syndrome and altered body composition in childre...
2 CitationsSource
#1Susana Santos (University of Porto)H-Index: 9
#2Milton Severo (University of Porto)H-Index: 22
Last. Andreia Oliveira (University of Porto)H-Index: 21
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#1Claire Monnereau (EUR: Erasmus University Rotterdam)H-Index: 6
#2Susana Santos (EUR: Erasmus University Rotterdam)H-Index: 9
Last. Janine F. Felix (EUR: Erasmus University Rotterdam)H-Index: 33
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Associations of adult genetic risk scores for adiposity with childhood abdominal, liver and pericardial fat assessed by magnetic resonance imaging
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#2Ziad AbdeenH-Index: 26
Last. Majid Ezzati (Imperial College London)H-Index: 107
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BACKGROUND: Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in ...
568 CitationsSource
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#1Connor A. Emdin (Broad Institute)H-Index: 16
#2Amit Khera (Broad Institute)H-Index: 52
Last. Sekar Kathiresan (Broad Institute)H-Index: 106
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Importance In observational studies, abdominal adiposity has been associated with type 2 diabetes and coronary heart disease (CHD). Whether these associations represent causal relationships remains uncertain. Objective To test the association of a polygenic risk score for waist-to-hip ratio (WHR) adjusted for body mass index (BMI), a measure of abdominal adiposity, with type 2 diabetes and CHD through the potential intermediates of blood lipids, blood pressure, and glycemic phenotypes. Design, S...
100 CitationsSource
#1Cilius Esmann Fonvig (UCPH: University of Copenhagen)H-Index: 9
#2Elizaveta Chabanova (Copenhagen University Hospital)H-Index: 14
Last. Jens-Christian Holm (UCPH: University of Copenhagen)H-Index: 22
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Ectopic fat deposition in liver and skeletal muscle tissue is related to cardiovascular disease risk and is a common metabolic complication in obese children. We evaluated the hypotheses of ectopic fat in these organs could be diminished following 1 year of multidisciplinary care specialized in childhood obesity, and whether this reduction would associate with changes in other markers of metabolic function. This observational longitudinal study evaluated 40 overweight children and adolescents en...
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#2Barbara RakitschH-Index: 9
Last. Oliver StegleH-Index: 47
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The multi-trait set test (mtSet) is an efficient mixed-model method that enables genome-wide association tests for large cohorts and multiple quantitative traits using sets of variants to improve power and sensitivity, while addressing confounding due to population structure.
48 CitationsSource
#1Louise Beltoft Borup Andersen (UCPH: University of Copenhagen)H-Index: 2
#2Christian B. Pipper (UCPH: University of Copenhagen)H-Index: 12
Last. Kim F. Michaelsen (UCPH: University of Copenhagen)H-Index: 76
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BACKGROUND/OBJECTIVES: Differences in the quality of complementary feeding between infants of obese and nonobesemothers have not been examined sufficiently. The aim of this paper was to compare dietary patterns, foods, nutrients and energyintakes of 9-month-old Danish infants in a cohort comprising obese mothers (SKOT II, n=184; SKOT, Danish abbreviation of smallchildren's diet and well-being) with a cohort consisting mainly of nonobese mothers (SKOT I, n=329).SUBJECTS/METHODS: Dietary intake was...
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#2Pilar Codoñer-Franch (University of Valencia)H-Index: 19
Last. Miguel Martí-Cabrera (University of Valencia)H-Index: 12
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Objective To study leukocyte–endothelium interaction, a measure of the initial phase of atheromatosis, in children with overweight or obesity. Study design A prospective study was conducted in 77 children aged 7-16 years; 47 were children with overweight/obesity and 30 were normal weight. Polymorphonuclear neutrophils (PMNs) and peripheral blood mononuclear cells were isolated from venous blood samples and the interaction of leukocytes over a monolayer of human umbilical vein endothelial cells w...
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