Per- and polyfluoroalkyl substances display structure-dependent inhibition towards UDP-glucuronosyltransferases
Abstract
Per- and polyfluoroalkyl substances (PFASs) are a large group of chemicals and can be detected in environmental and human samples all over the world. Toxicity of existing and emerging PFASs will be a long-term source of concern. This study aimed to investigate structure-dependent inhibitory effects of 14 PFASs towards the activity of 11 UDP-glucuronosyltransferase (UGT) isoforms. In vitro UGTs-catalyzed glucuronidation of 4-methylumbelliferone...
Paper Details
Title
Per- and polyfluoroalkyl substances display structure-dependent inhibition towards UDP-glucuronosyltransferases
Published Date
Nov 1, 2019
Journal
Volume
254
Pages
113093 - 113093
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