Match!

Environmental Surveillance of Polioviruses in Armenia, Colombia before Trivalent Oral Polio Vaccine Cessation

Published on Aug 23, 2019in Viruses3.811
· DOI :10.3390/v11090775
María Mercedes González5
Estimated H-index: 5
,
Magile Fonseca9
Estimated H-index: 9
+ 5 AuthorsLuis Sarmiento11
Estimated H-index: 11
Sources
Abstract
Although acute flaccid paralysis (AFP) surveillance is the “gold standard” for detecting cases of polio, environmental surveillance can provide supplementary information in the absence of paralytic poliomyelitis cases. This study aimed to detect the introduction and/or circulation of wild poliovirus or vaccine-derived polioviruses (VDPV) in wastewater, covering a significant population of Armenia, Colombia, before trivalent oral polio vaccine (OPV) cessation. Between March and September 2015, 24 wastewater samples were collected from eight study sites in eight communes of Armenia, Colombia. Virus detection and characterization were performed using both cell culture (i.e., RD or L20B cells) and RT-PCR. Polioviruses were isolated in 11 (45.8%) of 24 wastewater samples. All isolates were identified as Sabin strains (type 1 = 9, type 3 = 2) by intratypic differentiation. Type 2 poliovirus was not detected in any of the samples. No wild poliovirus or VDPV was detected among the isolates. Non-polio enterovirus was identified in 8.3% (2/24) of the samples. This study revealed the excretion of Sabin poliovirus from OPV-immunized individuals, as well as the absence of VDPV and wild poliovirus in wastewaters of Armenia, Colombia. This confirms that environmental surveillance is an effective method, as an additional support to AFP surveillance, to monitor poliovirus during the OPV-to-IPV (inactivated polio vaccine) transition period.
  • References (16)
  • Citations (0)
📖 Papers frequently viewed together
78% of Scinapse members use related papers. After signing in, all features are FREE.
References16
Newest
1 CitationsSource
Poliovirus surveillance plays a critical role in achieving and certifying eradication and will play a key role in the polio endgame. Environmental surveillance can provide an opportunity to detect circulating polioviruses prior to the observation of any acute flaccid paralysis cases. We completed a systematic review of peer-reviewed publications on environmental surveillance for polio including the search terms “environmental surveillance” or “sewage,” and “polio,” “poliovirus,” or “poliomyeliti...
11 CitationsSource
The Global Polio Eradication Initiative (GPEI) has made substantial progress since its launch in 1988; only 37 wild poliovirus type 1 (WPV1) cases were detected in 2016, the lowest annual count ever. Wild poliovirus type 3 has not been detected since November 2012, and wild poliovirus type 2 was officially declared eradicated in September 2015. This success is attributable to the wide use of live oral poliovirus vaccines (OPVs). Since 2001, numerous outbreaks were caused by the emergence of gene...
13 CitationsSource
Wild polioviruses still remain endemic in three countries (Afghanistan, Pakistan, and Nigeria) and re-emergency of wild polio has been reported in previously polio-free countries. Environmental surveillance has been used as a supplementary tool in monitoring the circulation of wild poliovirus (PVs) and/or vaccine-derived PVs even in the absence of acute flaccid paralysis cases. This study aimed to monitor the presence of polioviruses in wastewater samples collected at one wastewater treatment pl...
7 CitationsSource
#1Humayun Asghar (WHO: World Health Organization)H-Index: 7
#2Ousmane M. Diop (WHO: World Health Organization)H-Index: 14
Last. Sara A. Lowther (CDC: Centers for Disease Control and Prevention)H-Index: 15
view all 14 authors...
This article summarizes the status of environmental surveillance (ES) used by the Global Polio Eradication Initiative, provides the rationale for ES, gives examples of ES methods and findings, and summarizes how these data are used to achieve poliovirus eradication. ES complements clinical acute flaccid paralysis (AFP) surveillance for possible polio cases. ES detects poliovirus circulation in environmental sewage and is used to monitor transmission in communities. If detected, the genetic seque...
45 CitationsSource
#2Concepción F. Estívariz (CDC: Centers for Disease Control and Prevention)H-Index: 13
Last. Mark A. Pallansch (National Center for Immunization and Respiratory Diseases)H-Index: 63
view all 13 authors...
Alejandra Esteves-Jaramillo, Concepcion F. Estivariz, Silvia Penaranda, Vesta L. Richardson, Jesus Reyna, Diana L. Coronel, Veronica Carrion, Jose M. Landaverde, Steven G. F. Wassilak, Elda E. Perez-Sanchez, Irma Lopez-Martinez, Cara C. Burns, and Mark A. Pallansch Centro Nacional para la Salud de la Infancia y Adolescencia, Mexico DF; Global Immunization Division, Center for Global Health, Centers for Disease Control and Prevention, and Division of Viral Diseases, National Center for Immunizati...
12 CitationsSource
23 Citations
#1David R. Kilpatrick (National Center for Immunization and Respiratory Diseases)H-Index: 3
#2Karen Ching (National Center for Immunization and Respiratory Diseases)H-Index: 2
Last. Olen M. Kew (National Center for Immunization and Respiratory Diseases)H-Index: 53
view all 11 authors...
Vaccine-derived polioviruses (VDPVs) are associated with polio outbreaks and prolonged infections in individuals with primary immunodeficiencies. VDPV-specific PCR assays for each of the three Sabin oral poliovirus vaccine (OPV) strains were developed, targeting sequences within the VP1 capsid region that are selected for during replication of OPV in the human intestine. Over 2400 Sabin-related isolates and identified 755 VDPVs were screened. Sensitivity of all assays was 100%, while specificity...
25 CitationsSource
This study aims to explore a possible silent circulation of wild and vaccine-derived polioviruses in departments of Colombia with polio vaccination coverage of below 80%. The study collected 52 samples of wastewater concentrated as a result of precipitation with polyethylene glycol and sodium chloride. The viral detection was carried out through isolation and the identification through neutralization of the cytopathic effect, as well as through a conventional polymerase chain reaction following ...
1 CitationsSource
#1David R. Kilpatrick (National Center for Immunization and Respiratory Diseases)H-Index: 3
#2Chen-Fu Yang (National Center for Immunization and Respiratory Diseases)H-Index: 2
Last. Olen M. Kew (National Center for Immunization and Respiratory Diseases)H-Index: 53
view all 11 authors...
We have adapted our previously described poliovirus diagnostic reverse transcription-PCR (RT-PCR) assays to a real-time RT-PCR (rRT-PCR) format. Our highly specific assays and rRT-PCR reagents are designed for use in the WHO Global Polio Laboratory Network for rapid and large-scale identification of poliovirus field isolates.
125 CitationsSource
Cited By0
Newest