Coenzyme Q 10 alleviates tacrolimus‐induced mitochondrial dysfunction in kidney
Abstract
The major side effect of tacrolimus (Tac) is nephrotoxicity. We studied whether supplementation of coenzyme Q10, (CoQ10) a potent antioxidant, can reduce Tac-induced nephrotoxicity via improving mitochondrial function. In an in vitro study, CoQ10 reduced the production of Tac-induced mitochondrial reactive oxygen species and abolished the loss of mitochondrial membrane potential in proximal tubular cell line. Assessment of mitochondrial function...
Paper Details
Title
Coenzyme Q 10 alleviates tacrolimus‐induced mitochondrial dysfunction in kidney
Published Date
Aug 20, 2019
Journal
Volume
33
Issue
11
Pages
12288 - 12298
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