Haplotype analysis encompassing HTT gene in Chinese patients with Huntington's disease

Background and purpose Huntington's disease ( HD ) is a dominantly inherited neurodegenerative disorder with varied prevalence in different populations, which may be associated with specific haplotypes. This study aimed to explore the haplotypes encompassing the HTT gene in the Chinese population. Methods A total of 406 individuals with HD and 59 normal relatives from 253 families with HD were enrolled. A total of 29 tag single nucleotide...