Match!
Hong-Lei Li
Zhejiang University
Dominance (genetics)DiseaseHuntington's diseasePopulationMedicine
7Publications
2H-index
6Citations
What is this?
Publications 9
Newest
#1Hong-Rong Cheng (ZJU: Zhejiang University)H-Index: 1
#2Xiao-Yan Li (ZJU: Zhejiang University)H-Index: 1
Last. Zhi-Ying Wu (ZJU: Zhejiang University)H-Index: 3
view all 8 authors...
Source
#1Ling-Qi Ye (ZJU: Zhejiang University)H-Index: 1
#2Xiao-Yan Li (ZJU: Zhejiang University)H-Index: 1
Last. Zhi-Ying Wu (ZJU: Zhejiang University)H-Index: 6
view all 9 authors...
Abstract Introduction In the past few years, the β-amyloid 42 peptide and tau protein in cerebrospinal fluid (CSF) have become primary diagnostic biomarkers in differentiating Alzheimer's disease (AD) and cognitive normal controls. As we know, several neurodegenerative diseases have been reported to overlap with AD in neuropathology and clinical symptoms. To examine the discriminative utility of these biomarkers in AD and other neurodegenerative diseases, we measured them in a cohort of Chinese ...
Source
#1Xiao-Yan Li (ZJU: Zhejiang University)H-Index: 1
#2Hong-Lei Li (ZJU: Zhejiang University)H-Index: 2
Last. Zhi-Ying Wu (ZJU: Zhejiang University)H-Index: 3
view all 10 authors...
Source
#1Xiao-Yan Li (ZJU: Zhejiang University)H-Index: 1
#2Yan-Bin Zhang (Fujian Medical University)H-Index: 1
Last. Zhi-Ying Wu (ZJU: Zhejiang University)H-Index: 6
view all 8 authors...
Huntington’s disease (HD) is an autosomal dominant degenerative disease that mainly encompasses movement, cognition, and behavioral symptoms. The apolipoprotein E (APOE) gene is thought to be associated with many neurodegenerative diseases. Here, we enrolled a cohort of 223 unrelated Han Chinese patients with HD and 1241 unrelated healthy controls in Southeastern China and analyzed the correlation between APOE genotypes and HD phenotypes. The results showed that the frequency of the E4 allele (7...
1 CitationsSource
#1Bin Jiang (Fujian Medical University)H-Index: 1
#2Jiong Zhou (ZJU: Zhejiang University)H-Index: 1
Last. Zhi-Ying Wu (ZJU: Zhejiang University)H-Index: 6
view all 10 authors...
Abstract Familial Alzheimer's disease (FAD) is characterized by a positive family history of dementia and typically occurs at an early age with an autosomal dominant pattern of inheritance. Amyloid precursor protein (APP), presenilin1 (PSEN1), and presenilin2 (PSEN2) are the major causative genes of FAD. The spectrum of mutations in patients with FAD has been investigated extensively in the Caucasian population but rarely in the Chinese population. Here, we performed whole-exome sequencing in a ...
2 CitationsSource
#1Qing-Qing Tao (ZJU: Zhejiang University)H-Index: 2
#2Zhi-Jun Liu (Fudan University)H-Index: 8
Last. Zhi-Ying Wu (ZJU: Zhejiang University)H-Index: 1
view all 10 authors...
Abstract Many sporadic Alzheimer's disease (SAD) risk genes have been identified in the last decades, but most of them have not been consistently accepted. Here, we sought to identify SAD-associated genes and their potential mechanisms involved in SAD pathogenesis. A 2-stage design was employed. In stage 1, 95 variants in 75 genes that were previously reported as SAD-risk genes in Caucasian populations were evaluated in 1857 subjects (422 SAD patients and 1435 controls). In stage 2, a subset of ...
3 CitationsSource
#1Hong-Lei Li (ZJU: Zhejiang University)H-Index: 2
#2Yan-Bin Zhang (ZJU: Zhejiang University)
Last. Hao Yu (ZJU: Zhejiang University)
view all 7 authors...
Dementia is a broad category of neurodegenerative diseases that cause a decline in memory, the ability to acquiring knowledge and understanding that ultimately affect a person’s daily functioning. Other common symptoms include a decrease in the ability of attention, judgment, problem solving, comprehension, and production of language. Psychiatric problems are also very common in patients with dementia. Dementia is often sporadic, and the prevalence is associated with aging. The most common types...
Source
#1Li-Xi Li (ZJU: Zhejiang University)
#2Zhi-Jun Liu (ZJU: Zhejiang University)
Last. Sheng Chen (ZJU: Zhejiang University)
view all 6 authors...
Motor neuron disease (MND) is a group of neurological disorders which is characterized by selectively progressive degeneration of motor neurons in the brain and spinal cord. On the basis of the degree of upper or lower neuron involvement, MND is broadly divided into several subtypes: pure upper neuron diseases (primary lateral sclerosis), pure lower motor neuron diseases (progressive spinal muscular atrophy, progressive bulbar palsy, spinal muscular atrophy, X-linked spinal and bulbar muscular a...
Source
#1Hao Gang Wang (ZJU: Zhejiang University)
#2Hong-Lei Li (ZJU: Zhejiang University)H-Index: 2
Last. X. H. Yu (ZJU: Zhejiang University)
view all 4 authors...
This paper provides a quasi-three dimensional version of Multi-Level Green's Function Interpolation Method for multilayered problems. In this method the cross level interfaction phase is used to enhance the interpolation efficiency for the multilayered problems with vias and patches. The numerical analysis shows the efficiency of this method.
Source
1