Original paper
Regulation of PDE5 expression in human aorta and thoracic aortic aneurysms
Abstract
Aneurysms and dissections affecting thoracic aorta are associated with smooth muscle cell (SMC) dysfunction. NO/cGMP signaling pathway in smooth muscle cells has been shown to be affected in sporadic thoracic aortic aneurysms. We analyzed the mRNA levels of PDE5, a cGMP-hydrolyzing enzyme highly expressed in aortic SMCs, that regulates arterious vascular tone by lowering cGMP levels. We found that aortic tissue obtained from Marfan, tricuspid...
Paper Details
Title
Regulation of PDE5 expression in human aorta and thoracic aortic aneurysms
Published Date
Aug 21, 2019
Journal
Volume
9
Issue
1
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Notes
History