Original paper
Gut-associated IgA+ immune cells regulate obesity-related insulin resistance
Abstract
The intestinal immune system is emerging as an important contributor to obesity-related insulin resistance, but the role of intestinal B cells in this context is unclear. Here, we show that high fat diet (HFD) feeding alters intestinal IgA + immune cells and that IgA is a critical immune regulator of glucose homeostasis. Obese mice have fewer IgA + immune cells and less secretory IgA and IgA-promoting immune mediators. HFD-fed IgA-deficient mice...
Paper Details
Title
Gut-associated IgA+ immune cells regulate obesity-related insulin resistance
Published Date
Aug 13, 2019
Journal
Volume
10
Issue
1
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Notes
History