Cyp1B1expression patterns in the developing chick inner ear

Background Retinoic acid (RA) plays an important role in organogenesis as a paracrine signal through transcriptional regulation of an increasing number of known downstream target genes, regulating cell proliferation, and differentiation. During the development of the inner ear, RA directly governs the morphogenesis and specification processes mainly by means of RA‐synthesizing retinaldehyde dehydrogenase (RALDH) enzymes. Interestingly, CYP1B1, a...