How much drug-induced blood pressure reduction is effective and safe in heart failure?

High blood pressure (BP) is a major risk factor for the development of cardiovascular events and mortality, and the risk of cardiovascular disease is directly correlated with BP levels also within the range of normality [1]. In the last decades, intervention studies and clinical trials clearly demonstrated that a pharmacological reduction of BP reduces cardiovascular mortality and morbidity in patients with hypertension and/or high...