Nadph Oxidase – Derived Reactive Oxygen Species Augment Inflammatory Macrophage Responses Via Redox-Sensitive Histone Deacetylase-Dependent Epigenetic Mechanisms In Experimental Atherosclerosis

Background and Aims: Oxidative stress microenvironment shapes the phenotype of monocyte (Mon)-derived macrophage (Mac) in atherosclerosis. Histone acetylation-based epigenetic mechanisms have been implicated in Mac polarization. Thus far, the role of redox signaling in the regulation of inflammatory Mac (M1) functions remains elusive. The aim of this study was to explore the potential role of NADPH oxidase (Nox)-derived reactive oxygen species...