Joint profiling of DNA methylation and chromatin architecture in single cells
Abstract
We report a molecular assay, Methyl-HiC, that can simultaneously capture the chromosome conformation and DNA methylome in a cell. Methyl-HiC reveals coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the nucleus, and delineates heterogeneity of both the chromatin architecture and DNA methylome in a mixed population. It enables simultaneous characterization of cell-type-specific chromatin...
Paper Details
Title
Joint profiling of DNA methylation and chromatin architecture in single cells
Published Date
Aug 5, 2019
Journal
Volume
16
Issue
10
Pages
991 - 993
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Notes
History