A Step-Wedge in the Biochemical Diagnosis of Preeclampsia

Preeclampsia, a hypertensive disorder of pregnancy, is one of the leading causes of maternal and neonatal morbidity and mortality worldwide. Among the reasons for the great global burden of disease is the poor predictive value of high blood pressure and proteinuria (traditional markers for the disease) for related adverse outcomes (1). Angiogenic biomarkers developed and studied during the past decade are widely recognized as clinically...