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Clinical Chemistry
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6.89
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24223
Papers 24225
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Published on 2019in Clinical Chemistry6.89
Brett Gall , Joe M. El-Khoury5
Estimated H-index: 5
(Yale University)
A 28-year-old man with a history of opioid abuse, currently prescribed Suboxone® to manage his opioid use disorder, submitted a urine specimen for a drug screen to verify abstinence from illicit compounds and compliance with the prescribed medication. The specimen screened positive by immunoassay (IA) for oxycodone and buprenorphine. Based on these results, the physician requested confirmation testing by LC-MS/MS and requested help interpreting the results (Table 1). View this table: Table 1. Pa...
Published on 2019in Clinical Chemistry6.89
It-Koon Tan (SGH: Singapore General Hospital)
Fig. 1. Boat ride on a mountain lake in autumn. The natural beauty of the many different mountains, waterfalls, rivers, lakes, wetlands, and forests in China attracted me and prompted me to visit the diverse regions of this country multiple times to capture the unique and often spectacular scenery, or their impressions, in my paintings. One often finds idyllic villages with houses perched strategically on the top of cliffs overlooking a river or lake some hundred meters below. The mountain-top a...
Published on 2019in Clinical Chemistry6.89
Tony Badrick10
Estimated H-index: 10
,
Giuseppe Banfi31
Estimated H-index: 31
+ 3 AuthorsKen Sikaris24
Estimated H-index: 24
Published on 2019in Clinical Chemistry6.89
Natalie Chandler1
Estimated H-index: 1
(GOSH: Great Ormond Street Hospital),
Helena Ahlfors (GOSH: Great Ormond Street Hospital)+ 7 AuthorsLyn S. Chitty51
Estimated H-index: 51
(GOSH: Great Ormond Street Hospital)
Background: Noninvasive prenatal diagnosis (NIPD) for monogenic disorders has a high uptake by families. Since 2013, our accredited public health service laboratory has offered NIPD for monogenic disorders, predominantly for de novo or paternally dominantly inherited mutations. Here we describe the extension of this service to include definitive NIPD for a recessive condition, cystic fibrosis (CF). Methods: Definitive NIPD for CF was developed using next-generation sequencing. Validation was per...
Published on 2019in Clinical Chemistry6.89
Martijn van Faassen8
Estimated H-index: 8
(UMCG: University Medical Center Groningen),
Grytsje Bouma (UMCG: University Medical Center Groningen)+ 5 AuthorsIdo P. Kema34
Estimated H-index: 34
(UMCG: University Medical Center Groningen)
Background: Currently, several indole markers are measured separately to support diagnosis and follow-up of patients with neuroendocrine tumors (NETs). We have developed a sensitive mass spectrometry method that simultaneously quantifies all relevant tryptophan-related indoles (tryptophan, 5-hydroxytryptophan, serotonin, 5-hydroxyindoleacetic acid) in platelet-rich plasma. Direct-matrix derivatization was used to make the chemical properties of the indoles uniform and to improve the analytical s...
Published on 2019in Clinical Chemistry6.89
Ben O'Leary6
Estimated H-index: 6
(ICR: Institute of Cancer Research),
Sarah Hrebien6
Estimated H-index: 6
(ICR: Institute of Cancer Research)
+ 7 AuthorsSibylle Loibl58
Estimated H-index: 58
Background: Circulating tumor DNA (ctDNA) assays are increasingly used for clinical decision-making, but it is unknown how well different assays agree. We aimed to assess the agreement in ctDNA mutation calling between BEAMing (beads, emulsion, amplification, and magnetics) and droplet digital PCR (ddPCR), 2 of the most commonly used digital PCR techniques for detecting mutations in ctDNA. Methods: Baseline plasma samples from patients with advanced breast cancer enrolled in the phase 3 PALOMA-3...
Published on Sep 6, 2019in Clinical Chemistry6.89
Na Sun8
Estimated H-index: 8
,
Thomas Kunzke2
Estimated H-index: 2
+ 14 AuthorsNicolas Schlegel17
Estimated H-index: 17
(University of Würzburg)
Background: Adrenocortical carcinoma (ACC) is a rare tumor with variable prognosis even within the same tumor stage. Cancer-related sex hormones and their sulfated metabolites in body fluids can be used as tumor markers. The role of steroid sulfation in ACC has not yet been studied. MALDI mass spectrometry imaging (MALDI-MSI) is a novel tool for tissue-based chemical phenotyping. Methods: We performed phenotyping of formalin-fixed, paraffin-embedded tissue samples from 72 ACC by MALDI-MSI at a m...
Published on Sep 5, 2019in Clinical Chemistry6.89
Ken Takahashi1
Estimated H-index: 1
(Jikei University School of Medicine),
Ohsuke Migita8
Estimated H-index: 8
(St. Marianna University School of Medicine)
+ 9 AuthorsAikou Okamoto18
Estimated H-index: 18
(Jikei University School of Medicine)
Background: To avoid hemolytic disease of the fetus and newborn resulting from maternal alloantibodies against fetal Rh antigens, anti-D immunoglobulin is routinely administered to RhD-negative pregnant women in Japan. Fetal RHD genotyping using cell-free DNA may prevent unnecessary antibody administration; however, current PCR-based methods, which detect RHD deletion, do not address the higher rates of RHD-positive D antigen-negative alleles in nonwhite populations without additional inspection...
Published on Sep 3, 2019in Clinical Chemistry6.89
Monsurul Hoq1
Estimated H-index: 1
(University of Melbourne),
Susan Matthews (Flinders University)+ 7 AuthorsPaul Monagle44
Estimated H-index: 44
(University of Melbourne)
Background: Age-specific reference intervals (RIs) have been developed for biochemistry analytes in children. However, the ability to interpret results from multiple laboratories for 1 individual is limited. This study reports a head-to-head comparison of reference values and age-specific RIs for 30 biochemistry analytes for children across 5 analyzer types. Methods: Blood was collected from healthy newborns and children 30 days to Results: The variations of age-specific mean reference values be...
Published on May 17, 2019in Clinical Chemistry6.89
Sugarniya Subramaniam , Varinder Jeet5
Estimated H-index: 5
+ 2 AuthorsJyotsna Batra25
Estimated H-index: 25
BACKGROUND: Metabolic reprogramming is a hallmark of cancer. MicroRNAs (miRNAs) have been found to regulate cancer metabolism by regulating genes involved in metabolic pathways. Understanding this layer of complexity could lead to the development of novel therapeutic approaches. CONTENT: miRNAs are noncoding RNAs that have been implicated as master regulators of gene expression. Studies have revealed the role of miRNAs in the metabolic reprogramming of tumor cells, with several miRNAs both posit...
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