Clinical Chemistry
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#1Ruben E.A. Musson (UU: Utrecht University)H-Index: 2
#2Albert Huisman (UU: Utrecht University)H-Index: 15
Last.Hans Kemperman (UU: Utrecht University)H-Index: 18
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A 5-year-old boy was admitted with dyspnea, fever, night sweats, and unexplained bruising. Radiography revealed several pulmonary consolidations, and laboratory investigations showed marked hyperleukocytosis with 90% blasts. He was diagnosed with T-cell acute lymphoblastic leukemia. Hemoglobin (Hb)2 and potassium results in the subsequent days, during therapy, showed a sawtooth pattern [Fig. 1: central lab, solid dots; point of care (POC), open dots]. The physician was confused and unsure what H...
#1Alison Smith (University of Leeds)H-Index: 6
#2Bethany Shinkins (University of Leeds)H-Index: 11
Last.Mike P. Messenger (University of Leeds)H-Index: 1
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Background: For medical tests that have a central role in clinical decision-making, current guidelines advocate outcome-based analytical performance specifications. Given that empirical (clinical trial-style) analyses are often impractical or unfeasible in this context, the ability to set such specifications is expected to rely on indirect studies to calculate the impact of test measurement uncertainty on downstream clinical, operational, and economic outcomes. Currently, however, a lack of awar...
#1Jasper Boeddinghaus (University of Basel)H-Index: 16
#2Raphael Twerenbold (University of Basel)H-Index: 42
Last.Christian P. Müller (University of Basel)H-Index: 79
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BACKGROUND: We aimed to validate the clinical performance of the high-sensitivity cardiac troponin I [VITROS® Immunodiagnostic Products hs Troponin I (hs-cTnI-VITROS)] assay. METHODS: We enrolled patients presenting to the emergency department with symptoms suggestive of acute myocardial infarction (AMI). Final diagnoses were centrally adjudicated by 2 independent cardiologists considering all clinical information, including cardiac imaging: first, using serial hs-cTnT-Elecsys (primary analysis)...
#1Graeme Eisenhofer (TUD: Dresden University of Technology)H-Index: 79
Diagnosis and surveillance of gastroenteropancreatic neuroendocrine tumors (GEP-NETs)2 involve a repertoire of several different biochemical tests with some differences in utility according to classifications and guidelines from the North American Neuroendocrine Tumor Society (1) and the European Neuroendocrine Tumor Society (2). Measured biomarkers include plasma chromogranin A, urinary or plasma 5-hydroxyindole acetic acid, platelet or whole blood serotonin, serum neuron-specific enolase, and,...
#1Monica R. Hill (JHUSOM: Johns Hopkins University School of Medicine)
#2Mark R. Hopkins (JHUSOM: Johns Hopkins University School of Medicine)
Last.Claire E. Knezevic (JHUSOM: Johns Hopkins University School of Medicine)
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A 25-year-old woman presented to the emergency department with a 1-day history of nausea, fatigue, exertional lightheadedness, and a syncopal event without witnessed seizure activity or urinary incontinence. The patient had a past medical history of fibromyalgia and nonepileptiform seizure disorder, and she was prescribed oxycodone for use as needed (although she reported as “not really taking”) and ibuprofen for pain. She denied use of any other medications, illicit substances, or herbal supple...
Most laboratorians do not see patients, making it is easy to forget the critical role we play in our patient's health journey. Laboratory phlebotomists represent the face of the clinical laboratory. Frequently, they are the first and last caregiver a …
#1Elizabeth R. Lemoine (Harvard University)H-Index: 2
#2S. Ananth Karumanchi (Harvard University)H-Index: 75
Preeclampsia, a hypertensive disorder of pregnancy, is one of the leading causes of maternal and neonatal morbidity and mortality worldwide. Among the reasons for the great global burden of disease is the poor predictive value of high blood pressure and proteinuria (traditional markers for the disease) for related adverse outcomes (1). Angiogenic biomarkers developed and studied during the past decade are widely recognized as clinically sensitive and specific biomarkers, with excellent predictiv...
#1Tony BadrickH-Index: 12
#2Giuseppe BanfiH-Index: 34
Last.Ken SikarisH-Index: 24
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Medicine has traditionally relied on heuristic approaches in which knowledge is acquired through experience and self-learning. Pathology is information rich with quantitative and qualitative measurements such as history, images, and physiological data from which diagnosis and treatment decisions are made. This information is readily linked to patient outcome data and is therefore potentially invaluable in improving treatment. Thus, pathology is ripe for the application of tools that can effectiv...
#1Erik Munson (College of Health Sciences, Bahrain)H-Index: 8
#2Karen C. Carroll (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 57
In the study published by Potter et al. in this issue of Clinical Chemistry (1), 103 genomes under the auspices of either Gardnerella vaginalis or Gardnerella spp. contributed to the National Center for Biotechnology Information database were accessed with the goal of further elucidating subspecies or new species designations (termed genomospecies in the context of in silico analysis). This genus is one of several that can contribute to the dynamic disease entity of bacterial vaginosis. A Canadi...
#1Ying Yang (WHU: Wuhan University)H-Index: 42
#2Chang Zeng (NU: Northwestern University)H-Index: 2
Last.Song-Mei Liu (WHU: Wuhan University)H-Index: 17
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Background: Long-term complications of type 2 diabetes (T2D), such as macrovascular and microvascular events, are the major causes for T2D-related disability and mortality. A clinically convenient, noninvasive approach for monitoring the development of these complications would improve the overall life quality of patients with T2D and help reduce healthcare burden through preventive interventions. Methods: A selective chemical labeling strategy for 5-hydroxymethylcytosines (5hmC-Seal) was used t...
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