Osteoblasts grown on microroughened titanium surfaces regulate angiogenic growth factor production through specific integrin receptors
Abstract
Cellular attachment and response to biomaterials are mediated by integrin receptor binding to extracellular matrix proteins adsorbed onto the material surface. Osteoblasts interact with their substrates via several integrin complexes including fibronectin-binding α5β1 and collagen-binding α1β1 and α2β1. Knockdown of α2 or β1 integrin subunits inhibits the production of factors that promote an osteogenic microenvironment, including osteocalcin,...
Paper Details
Title
Osteoblasts grown on microroughened titanium surfaces regulate angiogenic growth factor production through specific integrin receptors
Published Date
Oct 1, 2019
Journal
Volume
97
Pages
578 - 586
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