Original paper
Repressive Gene Regulation Synchronizes Development with Cellular Metabolism
Abstract
Metabolic conditions affect the developmental tempo of animals. Developmental gene regulatory networks (GRNs) must therefore synchronize their dynamics with a variable timescale. We find that layered repression of genes couples GRN output with variable metabolism. When repressors of transcription or mRNA and protein stability are lost, fewer errors in Drosophila development occur when metabolism is lowered. We demonstrate the universality of...
Paper Details
Title
Repressive Gene Regulation Synchronizes Development with Cellular Metabolism
Published Date
Aug 1, 2019
Journal
Volume
178
Issue
4
Pages
980 - 992.e17
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Notes
History