Protein Amounts of the MYC Transcription Factor Determine Germinal Center B Cell Division Capacity
Abstract
High-affinity B cell selection in the germinal center (GC) is governed by signals delivered by follicular helper T (Tfh) cells to B cells. Selected B cells undergo clonal expansion and affinity maturation in the GC dark zone in direct proportion to the amount of antigen they capture and present to Tfh cells in the light zone. Here, we examined the mechanisms whereby Tfh cells program the number of GC B cell divisions. Gene expression analysis...
Paper Details
Title
Protein Amounts of the MYC Transcription Factor Determine Germinal Center B Cell Division Capacity
Published Date
Aug 1, 2019
Journal
Volume
51
Issue
2
Pages
324 - 336.e5
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