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Immunity
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#1Jason Gorman (NIH: National Institutes of Health)H-Index: 26
#2Rosemarie D. Mason (NIH: National Institutes of Health)H-Index: 5
Last.David R. Ambrozak (NIH: National Institutes of Health)H-Index: 31
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Summary HIV- and SIV-envelope (Env) trimers are both extensively glycosylated, and antibodies identified to date have been unable to fully neutralize SIVmac239. Here, we report the isolation, structure, and glycan interactions of antibody ITS90.03, a monoclonal antibody that completely neutralized the highly neutralization-resistant isolate, SIVmac239. The co-crystal structure of a fully glycosylated SIVmac239-gp120 core in complex with rhesus CD4 and the antigen-binding fragment of ITS90.03 at ...
#1Mashito Sakai (UCSD: University of California, San Diego)H-Index: 7
#2Mashito Sakai (UCSD: University of California, San Diego)H-Index: 1
Last.Zihou Deng (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 1
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Summary Tissue environment plays a powerful role in establishing and maintaining the distinct phenotypes of resident macrophages, but the underlying molecular mechanisms remain poorly understood. Here, we characterized transcriptomic and epigenetic changes in repopulating liver macrophages following acute Kupffer cell depletion as a means to infer signaling pathways and transcription factors that promote Kupffer cell differentiation. We obtained evidence that combinatorial interactions of the No...
#1Zeyu Chen (UPenn: University of Pennsylvania)H-Index: 4
#2Zhicheng Ji (Johns Hopkins University)
Last.Caiyue Xu (UPenn: University of Pennsylvania)H-Index: 2
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Summary TCF-1 is a key transcription factor in progenitor exhausted CD8 T cells (Tex). Moreover, this Tex cell subset mediates responses to PD-1 checkpoint pathway blockade. However, the role of the transcription factor TCF-1 in early fate decisions and initial generation of Tex cells is unclear. Single-cell RNA sequencing (scRNA-seq) and lineage tracing identified a TCF-1+Ly108+PD-1+ CD8 T cell population that seeds development of mature Tex cells early during chronic infection. TCF-1 mediated ...
#1Antonia Wallrapp (Brigham and Women's Hospital)H-Index: 2
#2Patrick Burkett (Brigham and Women's Hospital)H-Index: 18
Last.Rebecca H. Herbst (Broad Institute)H-Index: 2
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Summary Neuroimmune interactions have emerged as critical modulators of allergic inflammation, and type 2 innate lymphoid cells (ILC2s) are an important cell type for mediating these interactions. Here, we show that ILC2s expressed both the neuropeptide calcitonin gene-related peptide (CGRP) and its receptor. CGRP potently inhibited alarmin-driven type 2 cytokine production and proliferation by lung ILC2s both in vitro and in vivo. CGRP induced marked changes in ILC2 expression programs in vivo ...
#1Burkhard Becher (UZH: University of Zurich)H-Index: 61
#2Ari Waisman (University of Mainz)H-Index: 44
Last.Li-Fan Lu (UCSD: University of California, San Diego)H-Index: 26
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#1Tuan M. Tran (IU: Indiana University)H-Index: 18
#2Rajan GuhaH-Index: 1
Last.Safiatou Doumbo (University of the Sciences)H-Index: 1
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Summary Immunity that controls parasitemia and inflammation during Plasmodium falciparum (Pf) malaria can be acquired with repeated infections. A limited understanding of this complex immune response impedes the development of vaccines and adjunctive therapies. We conducted a prospective systems biology study of children who differed in their ability to control parasitemia and fever following Pf infection. By integrating whole-blood transcriptomics, flow-cytometric analysis, and plasma cytokine ...
Summary Increasing evidence indicates CD4+ T cells can recognize cancer-specific antigens and control tumor growth. However, it remains difficult to predict the antigens that will be presented by human leukocyte antigen class II molecules (HLA-II), hindering efforts to optimally target them therapeutically. Obstacles include inaccurate peptide-binding prediction and unsolved complexities of the HLA-II pathway. To address these challenges, we developed an improved technology for discovering HLA-I...
#1Lars Hangartner (Scripps Research Institute)H-Index: 18
Using a transgenic mouse strain expressing the human VH1-69 germline gene used by many broadly neutralizing antibodies to influenza A virus, Sangesland et al. show that the VH1-69 gene segment provides the essentials for mounting antibody responses against the conserved hemagglutinin stem epitope.
#1Charles L. Evavold (Harvard University)H-Index: 4
#2Jonathan C. Kagan (Harvard University)H-Index: 39
Inflammasomes are supramolecular organizing centers that operate to drive interleukin-1 (IL-1)-dependent inflammation. Depending on context, inflammatory caspases act upstream or downstream of inflammasome assembly, serving as the principal enzymes that control activities of these organelles. In this review, we discuss mechanisms of inflammasome assembly and signaling. We posit that upstream regulatory proteins, classically known as pattern-recognition receptors, operate to assess infectious and...
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