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Papers 4994
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Published in Immunity 21.52
Lucy Cooper (Monash University, Clayton campus), Kim L. Good-Jacobson12
Estimated H-index: 12
(Monash University, Clayton campus)
Class-switch recombination (CSR) provides diverse effector functions to B cells. In this issue of Immunity, Roco et al. (2019) refute long-standing dogma that germinal centers are the principal location for CSR; instead, CSR predominantly occurs early post immunization and declines during germinal center formation.
Published in Immunity 21.52
Johanna A. Knipper6
Estimated H-index: 6
(Edin.: University of Edinburgh),
Xiaolei Ding1
Estimated H-index: 1
(University of Cologne),
Sabine A. Eming36
Estimated H-index: 36
(University of Cologne)
In this issue of Immunity, Kimball et al. (2019) show that restoring expression of the chromatin modifying enzyme Setdb2 in macrophages rescues impaired wound healing associated with type 2 diabetes. Their findings reveal epigenetic regulation as central to the resolution of macrophage-mediated inflammation in tissue repair and have therapeutic implications for the treatment of diabetic wounds.
Published on Jun 1, 2019in Immunity 21.52
Michelle A. Mintz (UCSF: University of California, San Francisco), James H. Felce11
Estimated H-index: 11
(University of Oxford)
+ 11 AuthorsTakaharu Okada22
Estimated H-index: 22
Summary The tumor necrosis factor receptor superfamily member HVEM is one of the most frequently mutated surface proteins in germinal center (GC)-derived B cell lymphomas. We found that HVEM deficiency increased B cell competitiveness during pre-GC and GC responses. The immunoglobulin (Ig) superfamily protein BTLA regulated HVEM-expressing B cell responses independently of B-cell-intrinsic signaling via HVEM or BTLA. BTLA signaling into T cells through the phosphatase SHP1 reduced T cell recepto...
Published in Immunity 21.52
Liangliang Ji (THU: Tsinghua University), Xiaoyu Hu28
Estimated H-index: 28
(THU: Tsinghua University)
Formation of memory T cells is coupled with changes of metabolic status, yet how environmental metabolites affect the transition remains largely unknown. In this issue of Immunity, Bachem et al. (2019) report that microbiota-derived butyrate enhances the memory potential of CD8+ T cells via rewiring cellular metabolism.
Published in Immunity 21.52
Jonathan Roco3
Estimated H-index: 3
(ANU: Australian National University),
Luka Mesin12
Estimated H-index: 12
(Rockefeller University)
+ -3 AuthorsJean Cappello9
Estimated H-index: 9
(ANU: Australian National University)
Summary Class-switch recombination (CSR) is a DNA recombination process that replaces the immunoglobulin (Ig) constant region for the isotype that can best protect against the pathogen. Dysregulation of CSR can cause self-reactive BCRs and B cell lymphomas; understanding the timing and location of CSR is therefore important. Although CSR commences upon T cell priming, it is generally considered a hallmark of germinal centers (GCs). Here, we have used multiple approaches to show that CSR is trigg...
Published in Immunity 21.52
Akira Takeda10
Estimated H-index: 10
(UTU: University of Turku),
Maija Hollmén12
Estimated H-index: 12
(UTU: University of Turku)
+ -3 AuthorsHeikki Irjala12
Estimated H-index: 12
(TYKS: Turku University Hospital)
Summary Lymphatic vessels form a critical component in the regulation of human health and disease. While their functional significance is increasingly being recognized, the comprehensive heterogeneity of lymphatics remains uncharacterized. Here, we report the profiling of 33,000 lymphatic endothelial cells (LECs) in human lymph nodes (LNs) by single-cell RNA sequencing. Unbiased clustering revealed six major types of human LECs. LECs lining the subcapsular sinus (SCS) of LNs abundantly expressed...
Published on Jul 1, 2019in Immunity 21.52
Andrew Kimball6
Estimated H-index: 6
(UM: University of Michigan),
Frank M. Davis9
Estimated H-index: 9
(UM: University of Michigan)
+ 15 AuthorsDylan Nysz1
Estimated H-index: 1
(UM: University of Michigan)
Summary Macrophage plasticity is critical for normal tissue repair to ensure transition from the inflammatory to the proliferative phase of healing. We examined macrophages isolated from wounds of patients afflicted with diabetes and of healthy controls and found differential expression of the methyltransferase Setdb2. Myeloid-specific deletion of Setdb2 impaired the transition of macrophages from an inflammatory phenotype to a reparative one in normal wound healing. Mechanistically, Setdb2 trim...
Published in Immunity 21.52
Ruth Kennedy (St James's University Hospital), Ulf Klein (St James's University Hospital)
TNFRSF14, encoding the receptor HVEM, is frequently mutated in germinal center (GC)-derived B cell lymphomas. In this issue, Mintz et al. demonstrate that the HVEM-BTLA axis restrains T cell help to GC B cells. Mutation-associated loss of this interaction promotes B cell proliferation through exaggerated T cell help, explaining how HVEM loss contributes to GC lymphomagenesis and revealing a cell-extrinsic tumor-suppressor role for BTLA.
Published on Jul 1, 2019in Immunity 21.52
Shlomo Finkin (Rockefeller University), Harald Hartweger2
Estimated H-index: 2
(Rockefeller University)
+ 2 AuthorsMichel C. Nussenzweig128
Estimated H-index: 128
(Rockefeller University)
Summary High-affinity B cell selection in the germinal center (GC) is governed by signals delivered by follicular helper T (Tfh) cells to B cells. Selected B cells undergo clonal expansion and affinity maturation in the GC dark zone in direct proportion to the amount of antigen they capture and present to Tfh cells in the light zone. Here, we examined the mechanisms whereby Tfh cells program the number of GC B cell divisions. Gene expression analysis revealed that Tfh cells induce Myc expression...