Papers 5146
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#1Paula A. Agudelo Garcia (UPenn: University of Pennsylvania)
#2Shelley L. Berger (UPenn: University of Pennsylvania)H-Index: 86
Summary Most autoimmunity-associated SNPs in the genome map to noncoding regulatory regions in T cells, but the nature of underlying epigenetic mechanisms and any normal purpose in T cell differentiation remain unclear. In this issue of Immunity, Ohkura et al. establish that crucial SNPs linked to autoimmune disease are enriched in DNA regions of CpG demethylation that govern Treg cell development and function.
#1Justin Le (Children's Hospital Los Angeles)
#2Jeong Eun Park (Children's Hospital Los Angeles)
Last. Virginia Camacho (UAB: University of Alabama at Birmingham)H-Index: 1
view all 13 authors...
Summary The challenges in recapitulating in vivo human T cell development in laboratory models have posed a barrier to understanding human thymopoiesis. Here, we used single-cell RNA sequencing (sRNA-seq) to interrogate the rare CD34+ progenitor and the more differentiated CD34– fractions in the human postnatal thymus. CD34+ thymic progenitors were comprised of a spectrum of specification and commitment states characterized by multilineage priming followed by gradual T cell commitment. The earli...
#1Emilie Seydoux (Fred Hutchinson Cancer Research Center)
#1Emilie Seydoux (Fred Hutchinson Cancer Research Center)H-Index: 2
Last. Junli Feng (Fred Hutchinson Cancer Research Center)H-Index: 1
view all 20 authors...
Abstract Antibody responses develop following SARS-CoV-2 infection, but little is known about their epitope specificities, clonality, binding affinities, epitopes and neutralizing activity. We isolated B cells specific for the SARS-CoV-2 envelope glycoprotein spike (S) from a COVID-19-infected subject twenty-one days after the onset of clinical disease. Forty-five S-specific monoclonal antibodies were generated. They had undergone minimal somatic mutation, with limited clonal expansion and three...
2 CitationsSource
#1Yimeng Gao (Yale University)H-Index: 1
#2Radovan Vasic (Yale University)H-Index: 1
Last. Eriko Kudo (Yale University)
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Summary N6-methyladenosine (m6A) is the most abundant RNA modification, but little is known about its role in mammalian hematopoietic development. Here, we show that conditional deletion of the m6A writer METTL3 in murine fetal liver resulted in hematopoietic failure and perinatal lethality. Loss of METTL3 and m6A activated an aberrant innate immune response, mediated by the formation of endogenous double-stranded RNAs (dsRNAs). The aberrantly formed dsRNAs were long, highly m6A modified in thei...
#1Chetna Soni (NYU: New York University)H-Index: 2
#2Oriana A. Perez (NYU: New York University)H-Index: 1
Last. Gregory C. Ippolito (University of Texas at Austin)H-Index: 26
view all 12 authors...
Summary Class-switched antibodies to double-stranded DNA (dsDNA) are prevalent and pathogenic in systemic lupus erythematosus (SLE), yet mechanisms of their development remain poorly understood. Humans and mice lacking secreted DNase DNASE1L3 develop rapid anti-dsDNA antibody responses and SLE-like disease. We report that anti-DNA responses in Dnase1l3−/− mice require CD40L-mediated T cell help, but proceed independently of germinal center formation via short-lived antibody-forming cells (AFCs) ...
#1Jing Ni (DKFZ: German Cancer Research Center)H-Index: 1
#2Xi Wang (DKFZ: German Cancer Research Center)H-Index: 13
Last. Philipp-Sebastian Koch (Heidelberg University)H-Index: 4
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Summary Enhancing immune cell functions in tumors remains a major challenge in cancer immunotherapy. Hypoxia is a common feature of solid tumors, and cells adapt by upregulating the transcription factor HIF-1α. Here, we defined the transcriptional landscape of mouse tumor-infiltrating natural killer (NK) cells by using single-cell RNA sequencing. Conditional deletion of Hif1a in NK cells resulted in reduced tumor growth, elevated expression of activation markers, effector molecules, and an enric...
1 CitationsSource
#1Talyn Chu (TUM: Technische Universität München)
#2Dietmar Zehn (TUM: Technische Universität München)H-Index: 21
Exposure to chronic infection or malignant tumors triggers the differentiation of functionally impaired, so-called exhausted T cells. In this issue of Immunity, Beltra et al. reveal a multi-step developmental process that defines how T cells transition from proliferating progenitors into terminally differentiated exhausted T cells.
#1Meike Emma Willemijn Logtenberg (NKI-AVL: Netherlands Cancer Institute)H-Index: 1
#2Ferenc A. Scheeren (LUMC: Leiden University Medical Center)H-Index: 12
Last. Ton N. M. Schumacher (LUMC: Leiden University Medical Center)H-Index: 61
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Summary The cytotoxic activity of myeloid cells is regulated by a balance of signals that are transmitted through inhibitory and activating receptors. The Cluster of Differentiation 47 (CD47) protein, expressed on both healthy and cancer cells, plays a pivotal role in this balance by delivering a “don’t eat me signal” upon binding to the Signal-regulatory protein alpha (SIRPα) receptor on myeloid cells. Here, we review the current understanding of the role of the CD47-SIRPα axis in physiological...
#1Haley E. RandolphH-Index: 3
#1Haley E. Randolph (U of C: University of Chicago)H-Index: 1
Last. Luis B. BarreiroH-Index: 35
view all 2 authors...
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 19 its associated disease, COVID-19, has demonstrated the devastating impact of a novel, infectious 20 pathogen on a susceptible population. Here, we explain the basic concepts of herd immunity and 21 discuss its implications in the context of COVID-19.
2 CitationsSource
#1J. Justin Milner (UCSD: University of California, San Diego)H-Index: 5
#2Clara Toma (UCSD: University of California, San Diego)H-Index: 2
Last. John T. Crowl (UCSD: University of California, San Diego)H-Index: 1
view all 15 authors...
Summary Tissue-resident memory CD8+ T cells (Trm) provide host protection through continuous surveillance of non-lymphoid tissues. Using single-cell RNA-sequencing (scRNA-seq) and genetic reporter mice, we identified discrete lineages of intestinal antigen-specific CD8+ T cells, including a Blimp1hiId3lo tissue-resident effector cell population most prominent in the early phase of acute viral and bacterial infections and a molecularly distinct Blimp1loId3hi tissue-resident memory population that...
Top fields of study
Molecular biology
T cell
Immune system
Cell biology