Double-epoch subtraction reveals long-latency mismatch response in urethane-anaesthetized mice

Anaesthetized rodents are examined for their capacity to model human mismatch negativity (MMN). In the present study, oddball and deviant-alone control paradigms, with stimuli varying in frequency (ascending and descending) and intensity (louder and quieter), were presented to anaesthetized mice to determine whether they elicit a translational mismatch response (MMR).Resulting waveforms displayed long-latency (>200 ms post-stimulus) components,...